Guidelines on the appropriate use of animal models for developing therapies in multiple sclerosis

Beatriz Moreno, Carmen Espejo, Leyre Mestre, Margarita Suardiaz, Diego Clemente, Fernando de Castro, Óscar Fernández-Fernández, Xavier Montalban, Pablo Villoslada, Carmen Guaza

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15 Citations (Scopus)


Introduction. The advance in the achievement of efective therapies for multiple sclerosis (MS), the defnition of appropriate therapeutic windows and to establish better diagnostic and prognostic biomarkers have become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might be related to lack of adequacy of the preclinical studies in MS experimental animal models. Aim. To standardize the methodological protocols of experimental models by developing a set of guidelines for preclinical studies by groups of experts from REEM (Spanish Network for MS). Development. A guide with recommendations for the application of MS models including a detailed assessment of appropriate experimental models taking into account the objective of the study that has been presented. Standards and quality criteria necessary in a preclinical study have been included. Conclusions. Standardized animal models of MS are essential to increase the success of the preclinical fndings in order to transfer them to the clinical practice. © 2012 Revista de Neurología.
Original languageEnglish
Pages (from-to)114-124
JournalRevista de Neurologia
Issue number2
Publication statusPublished - 9 Feb 2012


  • Animal models
  • Experimental design
  • Multiple sclerosis
  • Preclinical research
  • Quality criteria


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