TY - JOUR
T1 - Growth differentiation factor 15 (Gdf-15) :
T2 - A novel biomarker associated with poorer respiratory function in covid-19
AU - Alserawan, Leticia
AU - Peñacoba, Patricia
AU - Orozco, Sandra
AU - Castillo, Diego
AU - Ortiz, Esther
AU - Martinez-Martinez, Laura
AU - Moga, Esther
AU - Domingo, Pere
AU - Castellvi, Ivan
AU - Juarez, Candido
AU - Mariscal, Anaís
PY - 2021
Y1 - 2021
N2 - It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and correlated them with clinical and laboratory parameters reflecting severity in 84 patients with COVID-19, finding that GDF-15 levels were higher in both patients than in 20 healthy controls and were higher in patients with poorer respiratory function. GDF-15 levels also correlated with interleukin-6, C-reactive protein, ferritin and D-dimer levels and with neutrophilia and lymphopenia. Of all the analysed biomarkers, GDF-15 showed the best area under the receiver operating characteristics curve in identifying patients with poor respiratory function. In conclusion, our data support GDF-15 as a biomarker associated with pulmonary impairment in COVID-19 and so can potentially be useful in stratifying COVID-19 cases by severity.
AB - It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and correlated them with clinical and laboratory parameters reflecting severity in 84 patients with COVID-19, finding that GDF-15 levels were higher in both patients than in 20 healthy controls and were higher in patients with poorer respiratory function. GDF-15 levels also correlated with interleukin-6, C-reactive protein, ferritin and D-dimer levels and with neutrophilia and lymphopenia. Of all the analysed biomarkers, GDF-15 showed the best area under the receiver operating characteristics curve in identifying patients with poor respiratory function. In conclusion, our data support GDF-15 as a biomarker associated with pulmonary impairment in COVID-19 and so can potentially be useful in stratifying COVID-19 cases by severity.
KW - GDF-15
KW - COVID-19
KW - Respiratory function
KW - Inflammation
KW - Biomarker
U2 - 10.3390/diagnostics11111998
DO - 10.3390/diagnostics11111998
M3 - Article
C2 - 34829345
SN - 2075-4418
VL - 11
JO - Diagnostics
JF - Diagnostics
IS - 11
ER -