Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C

M. Chillón, A. Bosch, J. Zabner, L. Law, D. Armentano, M.J. Welsh, B.L. Davidson

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Abstract

Group C adenovirus-mediated gene transfer to central nervous system cells is inefficient. We found that wild-type group D viruses, or recombinant adenovirus type 2 (Ad2) (group C) modified to contain Ad17 (group D) fiber, were more efficient in infecting primary cultures of neurons. Together with studies on primary vascular endothelial cells and tissue culture cell lines, our results indicate that there is not a universally applicable adenovirus serotype for use as a gene transfer vector.
Original languageEnglish
Pages (from-to)2537-2540
JournalJournal of Virology
Volume73
Issue number3
Publication statusPublished - 1 Jan 1999

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