Group A streptococcal meningitis in the antibiotic era

M. A. Baraldés; P. Domingo; A. Mauri; J. Monmany; M. Castellanos; R. Pericas; G. Vázquez

doi:10.1007/s100960050349

Group A streptococcal meningitis in the antibiotic era

M. A. Baraldés, P. Domingo, A. Mauri, J. Monmany, M. Castellanos, R. Pericas, G. Vázquez

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Abstract

A case of group A streptococcal meningitis is reported and the 51 cases reported in the literature since 1966 reviewed. A total of 24 men and 24 women were included in the study; the mean age (± SD) was 20.9 ± 25.5 years. Fifty-eight percent of the patients had comorbid conditions, 80% had a distant focus of infection, and 65.8% had blood cultures positive for group A streptococci. Seventy-five per cent of the patients were treated with penicillin. The overall case-fatality rate was 12% (6 patients). Sequelae were more prevalent among children (44%) than among adults (7.7%) (0R = 9,43; 95% CI, 1.02-438.95; P = 0.03). Group A streptococcus is a rare cause of pyogenic meningitis, affecting mainly children or adults with co-morbidity. Although the case-fatality rate is relatively low, neurological sequelae are frequent among survivors, especially children.

Original language	English
Pages (from-to)	572-578
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	18
Issue number	8
DOIs	https://doi.org/10.1007/s100960050349
Publication status	Published - 23 Nov 1999

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title = "Group A streptococcal meningitis in the antibiotic era",

abstract = "A case of group A streptococcal meningitis is reported and the 51 cases reported in the literature since 1966 reviewed. A total of 24 men and 24 women were included in the study; the mean age (± SD) was 20.9 ± 25.5 years. Fifty-eight percent of the patients had comorbid conditions, 80% had a distant focus of infection, and 65.8% had blood cultures positive for group A streptococci. Seventy-five per cent of the patients were treated with penicillin. The overall case-fatality rate was 12% (6 patients). Sequelae were more prevalent among children (44%) than among adults (7.7%) (0R = 9,43; 95% CI, 1.02-438.95; P = 0.03). Group A streptococcus is a rare cause of pyogenic meningitis, affecting mainly children or adults with co-morbidity. Although the case-fatality rate is relatively low, neurological sequelae are frequent among survivors, especially children.",

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AU - Baraldés, M. A.

AU - Domingo, P.

AU - Mauri, A.

AU - Monmany, J.

AU - Castellanos, M.

AU - Pericas, R.

AU - Vázquez, G.

PY - 1999/11/23

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N2 - A case of group A streptococcal meningitis is reported and the 51 cases reported in the literature since 1966 reviewed. A total of 24 men and 24 women were included in the study; the mean age (± SD) was 20.9 ± 25.5 years. Fifty-eight percent of the patients had comorbid conditions, 80% had a distant focus of infection, and 65.8% had blood cultures positive for group A streptococci. Seventy-five per cent of the patients were treated with penicillin. The overall case-fatality rate was 12% (6 patients). Sequelae were more prevalent among children (44%) than among adults (7.7%) (0R = 9,43; 95% CI, 1.02-438.95; P = 0.03). Group A streptococcus is a rare cause of pyogenic meningitis, affecting mainly children or adults with co-morbidity. Although the case-fatality rate is relatively low, neurological sequelae are frequent among survivors, especially children.

AB - A case of group A streptococcal meningitis is reported and the 51 cases reported in the literature since 1966 reviewed. A total of 24 men and 24 women were included in the study; the mean age (± SD) was 20.9 ± 25.5 years. Fifty-eight percent of the patients had comorbid conditions, 80% had a distant focus of infection, and 65.8% had blood cultures positive for group A streptococci. Seventy-five per cent of the patients were treated with penicillin. The overall case-fatality rate was 12% (6 patients). Sequelae were more prevalent among children (44%) than among adults (7.7%) (0R = 9,43; 95% CI, 1.02-438.95; P = 0.03). Group A streptococcus is a rare cause of pyogenic meningitis, affecting mainly children or adults with co-morbidity. Although the case-fatality rate is relatively low, neurological sequelae are frequent among survivors, especially children.

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