Granulomatous enteritis and lymphadenitis in Iberian pigs naturally infected with Lawsonia intracellularis

J. Segalés, J. M. Fernández-Salguero, G. Fructuoso, J. Quintana, C. Rosell, J. Pozo, M. L. De Arriba, P. Rubio, M. Domingo

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)


Intestinal samples and/or lymph nodes of two Iberian pigs from two different farms were submitted for histopathologic examination. Both pigs had proliferation of ileal and/or cecal crypts with almost complete absence of goblet cells. Infection by Lawsonia intracellularis was demonstrated by immunohistochemistry and polymerase chain reaction assay. The mesenteric lymph node of one pig had moderate lymphocyte depletion with granulomatous inflammation of the lymph node parenchyma. Histiocytes and multinucleated giant cells from the lymph node of one pig contained L. intracellularis antigen within the cytoplasm. This pig had also porcine circovirus type 2 (PCV-2) infection, but nucleic acid and antigen of this virus were not demonstrated in the lymph node. The second pig had lymphocyte depletion and marked granulomatous inflammation in Peyer's patches. Histiocytes and multinucleated giant cells in areas of granulomatous inflammation contained L. intracellularis antigen; no PCV-2 nucleic acid or antigen was detected in the tissues of this pig. This is the first description of granulomatous ileitis and lymphadenitis associated with L. intracellularis infection.
Original languageEnglish
Pages (from-to)343-346
JournalVeterinary Pathology
Publication statusPublished - 1 Dec 2001


  • Granulomatous inflammation
  • Iberian pigs
  • Immunohistochemistry
  • Lawsonia intracellularis


Dive into the research topics of 'Granulomatous enteritis and lymphadenitis in Iberian pigs naturally infected with Lawsonia intracellularis'. Together they form a unique fingerprint.

Cite this