Goat acetyl-coenzyme a carboxylase a: Molecular characterization, polymorphism, and association with milk traits

B. Badaoui; J. M. Serradilla; A. Tomàs; B. Urrutia; J. L. Ares; J. Carrizosa; A. Sànchez; J. Jordana; M. Amills

doi:10.3168/jds.S0022-0302(07)71590-4

Goat acetyl-coenzyme a carboxylase a: Molecular characterization, polymorphism, and association with milk traits

B. Badaoui, J. M. Serradilla, A. Tomàs, B. Urrutia, J. L. Ares, J. Carrizosa, A. Sànchez, J. Jordana, M. Amills

Department of Animal and Food Science

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Abstract

Acetyl-coenzyme A carboxylase α (ACACA), the major regulatory enzyme of fatty acid biosynthesis, catalyzes the conversion of acetyl-CoA to malonyl-CoA. We have sequenced 5.5 kb of the goat ACACA cDNA in 18 individuals. The translated cDNA sequence encodes 1,832 AA and shares a high AA identity (99%) with the ovine and bovine ACACA orthologous sequences. One silent single nucleotide polymorphism was identified at exon 45 (C5493T). The enotyping of this polymorphism in 4 goat breeds, Murciano-Granadina, Teramana, Majorera, and Malagueña, showed that it was segregating in all 4 breeds at variable frequencies. In addition, a mixed animal model was used to evaluate the association of C5493T genotypes with milk traits. Results from this study show that the C5493T mutation was suggestively associated with fat yield, lactose content, and somatic cell count. © American Dairy Science Association, 2007.

Original language	English
Pages (from-to)	1039-1043
Journal	Journal of Dairy Science
Volume	90
Issue number	2
DOIs	https://doi.org/10.3168/jds.S0022-0302(07)71590-4
Publication status	Published - 1 Jan 2007

Keywords

Acetyl-CoA carboxylase
Goat
Milk trait
Polymorphism

Access to Document

10.3168/jds.S0022-0302(07)71590-4

Fingerprint Dive into the research topics of 'Goat acetyl-coenzyme a carboxylase a: Molecular characterization, polymorphism, and association with milk traits'. Together they form a unique fingerprint.

Cite this

@article{762f478f601d4c8ba731cf3ed8cfa93e,

title = "Goat acetyl-coenzyme a carboxylase a: Molecular characterization, polymorphism, and association with milk traits",

abstract = "Acetyl-coenzyme A carboxylase α (ACACA), the major regulatory enzyme of fatty acid biosynthesis, catalyzes the conversion of acetyl-CoA to malonyl-CoA. We have sequenced 5.5 kb of the goat ACACA cDNA in 18 individuals. The translated cDNA sequence encodes 1,832 AA and shares a high AA identity (99%) with the ovine and bovine ACACA orthologous sequences. One silent single nucleotide polymorphism was identified at exon 45 (C5493T). The enotyping of this polymorphism in 4 goat breeds, Murciano-Granadina, Teramana, Majorera, and Malague{\~n}a, showed that it was segregating in all 4 breeds at variable frequencies. In addition, a mixed animal model was used to evaluate the association of C5493T genotypes with milk traits. Results from this study show that the C5493T mutation was suggestively associated with fat yield, lactose content, and somatic cell count. {\textcopyright} American Dairy Science Association, 2007.",

keywords = "Acetyl-CoA carboxylase, Goat, Milk trait, Polymorphism",

author = "B. Badaoui and Serradilla, {J. M.} and A. Tom{\`a}s and B. Urrutia and Ares, {J. L.} and J. Carrizosa and A. S{\`a}nchez and J. Jordana and M. Amills",

year = "2007",

month = jan,

day = "1",

doi = "10.3168/jds.S0022-0302(07)71590-4",

language = "English",

volume = "90",

pages = "1039--1043",

journal = "Journal of Dairy Science",

issn = "0022-0302",

publisher = "Elsevier Limited",

number = "2",

}

Goat acetyl-coenzyme a carboxylase a: Molecular characterization, polymorphism, and association with milk traits. / Badaoui, B.; Serradilla, J. M.; Tomàs, A.; Urrutia, B.; Ares, J. L.; Carrizosa, J.; Sànchez, A.; Jordana, J.; Amills, M.

In: Journal of Dairy Science, Vol. 90, No. 2, 01.01.2007, p. 1039-1043.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Goat acetyl-coenzyme a carboxylase a: Molecular characterization, polymorphism, and association with milk traits

AU - Badaoui, B.

AU - Serradilla, J. M.

AU - Tomàs, A.

AU - Urrutia, B.

AU - Ares, J. L.

AU - Carrizosa, J.

AU - Sànchez, A.

AU - Jordana, J.

AU - Amills, M.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Acetyl-coenzyme A carboxylase α (ACACA), the major regulatory enzyme of fatty acid biosynthesis, catalyzes the conversion of acetyl-CoA to malonyl-CoA. We have sequenced 5.5 kb of the goat ACACA cDNA in 18 individuals. The translated cDNA sequence encodes 1,832 AA and shares a high AA identity (99%) with the ovine and bovine ACACA orthologous sequences. One silent single nucleotide polymorphism was identified at exon 45 (C5493T). The enotyping of this polymorphism in 4 goat breeds, Murciano-Granadina, Teramana, Majorera, and Malagueña, showed that it was segregating in all 4 breeds at variable frequencies. In addition, a mixed animal model was used to evaluate the association of C5493T genotypes with milk traits. Results from this study show that the C5493T mutation was suggestively associated with fat yield, lactose content, and somatic cell count. © American Dairy Science Association, 2007.

AB - Acetyl-coenzyme A carboxylase α (ACACA), the major regulatory enzyme of fatty acid biosynthesis, catalyzes the conversion of acetyl-CoA to malonyl-CoA. We have sequenced 5.5 kb of the goat ACACA cDNA in 18 individuals. The translated cDNA sequence encodes 1,832 AA and shares a high AA identity (99%) with the ovine and bovine ACACA orthologous sequences. One silent single nucleotide polymorphism was identified at exon 45 (C5493T). The enotyping of this polymorphism in 4 goat breeds, Murciano-Granadina, Teramana, Majorera, and Malagueña, showed that it was segregating in all 4 breeds at variable frequencies. In addition, a mixed animal model was used to evaluate the association of C5493T genotypes with milk traits. Results from this study show that the C5493T mutation was suggestively associated with fat yield, lactose content, and somatic cell count. © American Dairy Science Association, 2007.

KW - Acetyl-CoA carboxylase

KW - Goat

KW - Milk trait

KW - Polymorphism

U2 - 10.3168/jds.S0022-0302(07)71590-4

DO - 10.3168/jds.S0022-0302(07)71590-4

M3 - Article

VL - 90

SP - 1039

EP - 1043

JO - Journal of Dairy Science

JF - Journal of Dairy Science

SN - 0022-0302

IS - 2

ER -