Gluts and mammalian sperm metabolism

Diego Bucci, Juan Enrique Rodriguez-Gil, Claudia Vallorani, Marcella Spinaci, Giovanna Galeati, Carlo Tamanini

Research output: Contribution to journalReview articleResearchpeer-review

50 Citations (Scopus)

Abstract

Mammalian cells use glucides as a substrate that can be catabolized through glycolitic pathways or oxidative phosphorylation, used as a source of reducing potential, or used for anabolic aims. An important role in supplying cells with energy is played by different membrane proteins that can actively (sodium-dependent glucose transporters) or passively (glucose transporters; GLUT) transport hexoses through the lipidic bilayer. In particular, GLUTs are a family of 13 proteins that facilitate the transport of sugars and have a peculiar distribution in different tissues as well as a particular affinity for substrates. These proteins are also present in mature sperm cells, which, in fact, need carriers for uptake energetic sources that are important for maintaining cell basic activity as well as specific functions, such asmotility and fertilization ability. Likewise, several GLUTs have been studied in various mammalian species (man, bull, rat, mouse, boar, dog, stallion, and donkey) to point out both their actual presence or absence and their localization on plasma membrane. The aim of this work is to give an overall picture of the studies available on GLUTs in mammalian spermatozoa at this moment, pointing out the species peculiarity, the possible role of these proteins, and the potential future research on this item. © American Society of Andrology.
Original languageEnglish
Pages (from-to)348-355
JournalJournal of Andrology
Volume32
Issue number4
DOIs
Publication statusPublished - 1 Jul 2011

Keywords

  • Acrosome reaction
  • Capacitation
  • Energy management
  • Energy uptake
  • Species-specificity
  • Spermatozoa

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