Glomerular filtration rate and/or ratio of urine albumin to creatinine as markers for diabetic retinopathy: A ten-year follow-up study

Pedro Romero-Aroca, Marc Baget-Bernaldiz, Raul Navarro-Gil, Antonio Moreno-Ribas, Aida Valls-Mateu, Ramon Sagarra-Alamo, Joan F. Barrot-De La Puente, Xavier Mundet-Tuduri

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

© 2018 Pedro Romero-Aroca et al. Aims. To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients. Methods. A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (EGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Results. Annual incidence of any-DR was 8.21 ± 0.60% (7.06%?8.92%), sight-threatening diabetic retinopathy (STDR) was 2.65 ± 0.14% (2.48%?2.88%), and diabetic macular edema (DME) was 2.21 ± 0.18% (2%?2.49%). Renal study results were as follows: UACR > 30 mg/g had an annual incidence of 7.02 ± 0.05% (6.97%?7.09%), EGFR < 60 ml/min/1.73 m2 incidence was 5.89 ± 0.12% (5.70%?6.13%). Cox?s proportional regression analysis of DR incidence shows that renal function studied by EGFR < 60 ml/min/1.73 m2 was less significant (p = 0 04, HR 1.223, 1.098?1.201) than UACR = 300 mg/g (p < 0 001, HR 1.485, 1.103?1.548). The study of STDR shows that EGFR < 60 ml/min/1.73 m2 was significant (p = 0 02, HR 1.890, 1.267?2.820), UACR = 300 mg/g (p < 0 001, HR 2.448, 1.595?3.757), and DME shows that EGFR < 60 ml/min/1.73 m2 was significant (p = 0 02, HR 1.920, 1.287?2.864) and UACR = 300 mg/g (p < 0 001, HR 2.432, 1.584?3.732). Conclusions. The UACR has a better association with diabetic retinopathy than the EGFR, although both are important risk factors for diabetic retinopathy.
Original languageEnglish
Article number5637130
JournalJournal of Diabetes Research
Volume2018
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint Dive into the research topics of 'Glomerular filtration rate and/or ratio of urine albumin to creatinine as markers for diabetic retinopathy: A ten-year follow-up study'. Together they form a unique fingerprint.

Cite this