TY - JOUR
T1 - Glial Response and Neuroinflammation in Cerebrocortical Atrophy in a Young Irish Wolfhound Dog
AU - Sant’Ana, Fabiano J. F. de
AU - Omaña, Miguel
AU - Blasco, Ester
AU - Pumarola Batlle, Marti
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1/11
Y1 - 2021/1/11
N2 - A two-year-old, Irish Wolfhound dog presented with a history of progressive neurological signs. Neurological exam revealed disorientation, absence of menace response, reduction of right nasal sensation, hypermetria and ataxia with reduction of proprioception in all four limbs. MRI findings were compatible with laminar neuronal necrosis and possible bilateral cortical cerebral atrophy. Grossly, a severe bilateral reduction of the gray matter with flattening of gyri, mainly in frontal and parietal cerebral areas, was observed. Histologically, multiple, segmental, bilateral, and symmetric areas of neuronal loss, necrosis and degeneration, in a laminar pattern, associated with a reactive gliosis were observed. Immunohistochemical studies showed severe reduction of neuronal bodies, proliferation and hypertrophy of astrocytes and microglia. Few perivascular B and T cells were demonstrated. Based on these data, we show some of the neuroinflammatory events that occur during CNS repair in a chronic phase of this condition.
AB - A two-year-old, Irish Wolfhound dog presented with a history of progressive neurological signs. Neurological exam revealed disorientation, absence of menace response, reduction of right nasal sensation, hypermetria and ataxia with reduction of proprioception in all four limbs. MRI findings were compatible with laminar neuronal necrosis and possible bilateral cortical cerebral atrophy. Grossly, a severe bilateral reduction of the gray matter with flattening of gyri, mainly in frontal and parietal cerebral areas, was observed. Histologically, multiple, segmental, bilateral, and symmetric areas of neuronal loss, necrosis and degeneration, in a laminar pattern, associated with a reactive gliosis were observed. Immunohistochemical studies showed severe reduction of neuronal bodies, proliferation and hypertrophy of astrocytes and microglia. Few perivascular B and T cells were demonstrated. Based on these data, we show some of the neuroinflammatory events that occur during CNS repair in a chronic phase of this condition.
KW - Cerebral cortical atrophy
KW - Immunohistochemistry
KW - Neuronal necrosis
KW - Neuropathology
UR - http://www.scopus.com/inward/record.url?scp=85099367528&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/ani11010143
DO - https://doi.org/10.3390/ani11010143
M3 - Article
C2 - 33440672
VL - 11
SP - 1
EP - 7
JO - Animals
JF - Animals
SN - 2076-2615
IS - 1
M1 - 143
ER -