Glial Response and Neuroinflammation in Cerebrocortical Atrophy in a Young Irish Wolfhound Dog

Fabiano J. F. de Sant’Ana, Miguel Omaña, Ester Blasco, Marti Pumarola Batlle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A two-year-old, Irish Wolfhound dog presented with a history of progressive neurological signs. Neurological exam revealed disorientation, absence of menace response, reduction of right nasal sensation, hypermetria and ataxia with reduction of proprioception in all four limbs. MRI findings were compatible with laminar neuronal necrosis and possible bilateral cortical cerebral atrophy. Grossly, a severe bilateral reduction of the gray matter with flattening of gyri, mainly in frontal and parietal cerebral areas, was observed. Histologically, multiple, segmental, bilateral, and symmetric areas of neuronal loss, necrosis and degeneration, in a laminar pattern, associated with a reactive gliosis were observed. Immunohistochemical studies showed severe reduction of neuronal bodies, proliferation and hypertrophy of astrocytes and microglia. Few perivascular B and T cells were demonstrated. Based on these data, we show some of the neuroinflammatory events that occur during CNS repair in a chronic phase of this condition.

Original languageEnglish
Article number143
Pages (from-to)1-7
Number of pages7
JournalAnimals
Volume11
Issue number1
DOIs
Publication statusPublished - 11 Jan 2021

Keywords

  • Cerebral cortical atrophy
  • Immunohistochemistry
  • Neuronal necrosis
  • Neuropathology

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