TY - JOUR
T1 - Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: Contemporary approach, current clinical significance and sources of pathology discrepancies
AU - Montironi, Rodolfo
AU - Mazzuccheli, Roberta
AU - Scarpelli, Marina
AU - Lopez-Beltran, Antonio
AU - Fellegara, Giovanni
AU - Algaba, Ferran
PY - 2005/5/6
Y1 - 2005/5/6
N2 - The Gleason grading system is a powerful tool to prognosticate and aid in the treatment of men with prostate cancer. The needle biopsy Gleason score correlates with virtually all other pathological variables, including tumour volume and margin status in radical prostatectomy specimens, serum prostate-specific antigen levels and many molecular markers. The Gleason score assigned to the tumour at radical prostatectomy is the most powerful predictor of progression after radical prostatectomy. However, there are significant deficiencies in the practice of this grading system. Not only are there problems among practising pathologists but also a relative lack of interobserver reproducibility among experts.
AB - The Gleason grading system is a powerful tool to prognosticate and aid in the treatment of men with prostate cancer. The needle biopsy Gleason score correlates with virtually all other pathological variables, including tumour volume and margin status in radical prostatectomy specimens, serum prostate-specific antigen levels and many molecular markers. The Gleason score assigned to the tumour at radical prostatectomy is the most powerful predictor of progression after radical prostatectomy. However, there are significant deficiencies in the practice of this grading system. Not only are there problems among practising pathologists but also a relative lack of interobserver reproducibility among experts.
KW - Biopsy
KW - Gleason score
KW - Prostate cancer
KW - Radical prostatectomy
U2 - 10.1111/j.1464-410X.2005.05540.x
DO - 10.1111/j.1464-410X.2005.05540.x
M3 - Review article
VL - 95
SP - 1146
EP - 1152
IS - 8
ER -
