Giant cell myocarditis: Monocytic immunophenotype of giant cells in a case associated with ulcerative colitis

Aurelio Ariza, M. Dolores López, JoséL Mate, Antoni Curós, María Villagrasa, JoséJ Navas-palacios

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33 Citations (Scopus)

Abstract

Giant cell myocarditis (GCM) is a rare condition whose histologic hallmark, the multinucleate giant cell, is of debated origin (monocytic v myogenic). We report the case of a 46-year-old woman with a previous diagnosis of ulcerative colitis who rapidly deteriorated and died as the result of refractory ventricular tachyarrhythmias. Postmortem examination showed a diffuse infiltratation of the myocardium by round cells and multinucleate giant cells. Immunohistochemically, round cells were demonstrated to be T lymphocytes admixed with monocytes. Multinucleate giant cells expressed monocytic markers (MAC 387, lysozyme) and were negative for muscle markers (actin, desmin, myoglobin). This case illustrates the monocytic and macrophagic nature of multinucleate giant cells and lends support to the autoimmune hypothesis of GCM by the concurrence of the latter with ulcerative colitis. © 1995.
Original languageEnglish
Pages (from-to)121-123
JournalHuman Pathology
Volume26
DOIs
Publication statusPublished - 1 Jan 1995

Keywords

  • giant cell myocarditis
  • macrophage
  • monocyte
  • ulcerative colitis

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