Ghrelin and apolipoprotein aiv levels show opposite trends to leptin levels during weight loss in morbidly obese patients

E. Pardina, M. D. López-Tejero, R. Llamas, R. Catalán, R. Galard, H. Allende, V. Vargas, A. Lecube, J. M. Fort, J. A. Baena-Fustegueras, J. Peinado-Onsurbe

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35 Citations (Scopus)


Background: Although bariatric surgery is the most common procedure used to induce weight loss in morbidly obese patients, its effect on plasma satiety factors (leptin, ghrelin, and apolipoprotein (apo)-AIV) is controversial. The aim of this work was to analyze these parameters before and at different times after surgery. Methods: Plasma was obtained from 34 patients before undergoing Roux-en-Y gastric bypass and during weight loss in the 12 months following surgery. Results: Morbidly obese patients had significantly higher values (147%) of leptin than normal-weight (NW) persons, while their ghrelin levels were 46% less than NW. Apo-AIV levels had approximately the same value in both groups (obese and NW). During weight loss, leptin decreased by 75% and ghrelin increased by 78%. Both parameters reached values less than or near NW, respectively, at 1 year after surgery. During the first month after surgery, apo-AIV plasma levels decreased (47%) but later increased and finally returned to preoperative values. Apo-AIV levels were correlated negatively with leptin and positively with ghrelin. High-density lipoprotein (HDL) levels were positively correlated with those of ghrelin and apo-AIV. Conclusions: During weight loss, plasma leptin and ghrelin could be good markers of total fat decrease. Ghrelin could also indicate gastric mucous improvement, whereas apo-AIV could indicate the recovery of intestinal function. Changes produced in the HDL levels of morbidly obese patients during weight loss suggest a decreased risk of coronary disease. © 2009 Springer Science + Business Media, LLC.
Original languageEnglish
Pages (from-to)1414-1423
JournalObesity Surgery
Issue number10
Publication statusPublished - 1 Oct 2009


  • Bariatric surgery
  • HDL
  • Satiety

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