Genotoxicity testing of five compounds in three Drosophila short-term somatic assays

M. Batiste-Alentorn, N. Xamena, A. Creus, R. Marcos

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11 Citations (Scopus)

Abstract

To provide further background data for the somatic mutation and/or recombination tests in Drosophila melanogaster, we have evaluated the responses in 3 assyas (zeste-white, white-ivory and wing spot) of 5 chemicals classified by the U.S. National Toxicology Program (NTP) as genotoxic non-carcinogens (or ambiguous). The selected compounds were 2-chloromethylpyridine, 1-nitronaphthalene, 4-nitro-o-phenylenediamine, 3-nitropropionic acid and p-phenylenediamine. Our results show that all the compounds tested produce significant increases in the frequency of mutant clones, in at least one of the assays, p-phenylenediamine being the compound which present a clearer mutagenic activity, and the wing spot test, the assay the detects more genotoxic compounds (4/5). © 1995.
Original languageEnglish
Pages (from-to)161-167
JournalMutation Research/Genetic Toxicology
Volume341
Issue number3
DOIs
Publication statusPublished - 1 Jan 1995

Keywords

  • Drosophila melanogaster
  • Genotoxicity testing
  • Short-term test
  • Somatic mutation and recombination

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