TY - JOUR
T1 - Genotoxicity studies with the unstable Zeste‐White (UZ) system of Drosophila melanogaster: Results with ten carcinogenic compounds
AU - Batiste‐Alentorn, M.
AU - Xamena, N.
AU - Creus, A.
AU - Marcos, R.
AU - Aaron, C. S.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - To increase the number of chemicals tested using the zeste‐white (UZ) somatic mutation assay, ten selected carcinogens (acetamide, acrylamide, benzo(α)pyrene, cyclophospha‐mide, diethylstilbestrol, 4‐nitroquinoline N‐oxide, propyleneimine, safrole, thiourea, and o‐toluidine) have been evaluated in this assay. Our results show that all the compounds tested produce significant increases in the eye spot frequency at, at least, one of the concentrations assayed, indicating that the zeste‐white assay appears to be highly sensitive to these carcinogenic compounds. That is in agreement with data previously reported by other authors. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
AB - To increase the number of chemicals tested using the zeste‐white (UZ) somatic mutation assay, ten selected carcinogens (acetamide, acrylamide, benzo(α)pyrene, cyclophospha‐mide, diethylstilbestrol, 4‐nitroquinoline N‐oxide, propyleneimine, safrole, thiourea, and o‐toluidine) have been evaluated in this assay. Our results show that all the compounds tested produce significant increases in the eye spot frequency at, at least, one of the concentrations assayed, indicating that the zeste‐white assay appears to be highly sensitive to these carcinogenic compounds. That is in agreement with data previously reported by other authors. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
KW - carcinogens
KW - genotoxic evaluation
KW - somatic mutation
U2 - 10.1002/em.2850180207
DO - 10.1002/em.2850180207
M3 - Article
SN - 0893-6692
VL - 18
SP - 120
EP - 125
JO - Environmental and Molecular Mutagenesis
JF - Environmental and Molecular Mutagenesis
IS - 2
ER -