Genotoxicity of tritiated water in human lymphocytes

G. Ribas; E. Carbonell; N. Xamena; A. Creus; R. Marcos

doi:10.1016/0378-4274(94)90145-7

Genotoxicity of tritiated water in human lymphocytes

G. Ribas, E. Carbonell, N. Xamena, A. Creus, R. Marcos

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that β-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE. © 1994.

Original language	English
Pages (from-to)	63-69
Journal	Toxicology Letters
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(94)90145-7
Publication status	Published - 1 Jan 1994

Keywords

Chromosome aberrations
Genotoxicity
Human lymphocyte
Sister-chromatid exchange
Tritiated water

Access to Document

10.1016/0378-4274(94)90145-7

Cite this

@article{e03e200a6c584f50a925aa283b8cf02d,

title = "Genotoxicity of tritiated water in human lymphocytes",

abstract = "The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that β-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE. {\textcopyright} 1994.",

keywords = "Chromosome aberrations, Genotoxicity, Human lymphocyte, Sister-chromatid exchange, Tritiated water",

author = "G. Ribas and E. Carbonell and N. Xamena and A. Creus and R. Marcos",

year = "1994",

month = jan,

day = "1",

doi = "10.1016/0378-4274(94)90145-7",

language = "English",

volume = "70",

pages = "63--69",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - Genotoxicity of tritiated water in human lymphocytes

AU - Ribas, G.

AU - Carbonell, E.

AU - Xamena, N.

AU - Creus, A.

AU - Marcos, R.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that β-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE. © 1994.

AB - The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that β-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE. © 1994.

KW - Chromosome aberrations

KW - Genotoxicity

KW - Human lymphocyte

KW - Sister-chromatid exchange

KW - Tritiated water

U2 - 10.1016/0378-4274(94)90145-7

DO - 10.1016/0378-4274(94)90145-7

M3 - Article

SN - 0378-4274

VL - 70

SP - 63

EP - 69

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1

ER -

Genotoxicity of tritiated water in human lymphocytes

Abstract

Keywords

Access to Document

Fingerprint

Cite this