Genotoxicity of commercial petrol samples in cultured human lymphocytes

Marià Pitarque, Elisabet Carbonell, Noel Xamena, Amadeu Creus, Ricardo Marcos

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Abstract

Different concentrations of two petrol commercial samples, leaded and unleaded, were evaluated for genotoxicity in human peripheral blood lymphocyte cultures. Sister-chromatid exchanges (SCE) and micronuclei (MN) were scored as genetic endpoints to measure the genotoxicity of the samples in cultures set up from three different healthy donors. The treatment of the cell culture was done employing different petrol concentrations (from 0.019 to 0.312 μl/ml) From our results we can conclude that both petrol samples induced a slight but concentration-dependent increase in the frequency of SCE, while no increase was detected in the MN frequency.
Original languageEnglish
Pages (from-to)15-21
JournalRevista Internacional de Contaminacion Ambiental
Volume13
Issue number1
Publication statusPublished - 1 Dec 1997

Keywords

  • Human lymphocyte cultures
  • Micronuclei
  • Petrol
  • Sister-chromatid exchanges

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