Genotoxic evaluation of the antimicrobial drug, trimethoprim, in cultured human lymphocytes

A. Abou-Eisha, A. Creus, R. Marcos

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19 Citations (Scopus)


The antimicrobial drug, trimethoprim, was evaluated for genotoxicity in human peripheral blood lymphocyte cultures set-up from two healthy donors. Sister-chromatid exchanges (SCE) and micronuclei (MN) were scored as genetic endpoints. The treatment was done using different trimethoprim concentrations ranging from 1 to 100 μg/ml. From our results, we can conclude that this drug is able to induce both cytotoxic and moderate genotoxic effects, as revealed by the increases seen in SCE and MN frequencies in cultures from the two donors and, at least, at one of the concentrations tested. Copyright (C) 1999 Elsevier Science B.V.
Original languageEnglish
Pages (from-to)157-162
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Issue number2
Publication statusPublished - 6 Apr 1999


  • Diaminopyrimidine
  • Human lymphocyte
  • Micronucleus
  • Sister chromatid exchange (SCE)
  • Trimethoprim


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