Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity

Aleix Prat, Barbara Adamo, Cheng Fan, Vicente Peg, Maria Vidal, Patricia Galván, Ana Vivancos, Paolo Nuciforo, Héctor G. Palmer, Shaheenah Dawood, Jordi Rodón, Santiago Ramony Cajal, Josep Maria Del Campo, Enriqueta Felip, Josep Tabernero, Javier Cortés

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.
Original languageEnglish
Article number3544
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 18 Dec 2013

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