Genome-wide association study on differentiated thyroid cancer

Aleksandra Köhler, Bowang Chen, Federica Gemignani, Rossella Elisei, Cristina Romei, Gisella Figlioli, Monica Cipollini, Alfonso Cristaudo, Franco Bambi, Per Hoffmann, Stefan Herms, Michał Kalemba, Dorota Kula, Shelley Harris, Peter Broderick, Richard Houlston, Susana Pastor, Ricard Marcos, Antonia Velázquez, Barbara JarzabKari Hemminki, Stefano Landi, Asta Försti

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58 Citations (Scopus)

Abstract

Context: Genome-wide association studies (GWASs) of differentiated thyroid cancer (DTC) have identified associations with polymorphisms at 2q35 (DIRC3), 8p12 (NRG1), 9q22.33 (FOXE1), and 14q13.2 (NKX2-1). However, most of the inherited genetic risk factors of DTC remain to be discovered. Objective: Our objective was to identify additional common DTC susceptibility loci. Design: We conducted a GWAS in a high-incidence Italian population of 690 cases and 497 controls and followed up the most significant polymorphisms in 2 additional Italian series and in 3 low-incidence populations totaling 2958 cases and 3727 controls. Results: After excluding the most robust previously identified locus (9q22.33), the strongest association was shown by rs6759952, confirming the recently published association in DIRC3 (odds ratio [OR] = 1.21, P = 6.4 × 10-10, GWAS and all replications combined). Additionally, in the combined analysis of the Italian series, suggestive associations were attained with rs10238549 and rs7800391 in IMMP2L (OR = 1.27, P = 4.1 × 10 -6; and OR= 1.25, P= 5.7 × 10-6), rs7617304 in RARRES1 (OR = 1.25, P = 4.6 × 10-5) and rs10781500 in SNAPC4/CARD9 (OR = 1.23, P = 3.5 × 10-5). Conclusions: Our findings provide additional insights into the genetic and biological basis of inherited genetic susceptibility to DTC. Additional studies are needed to determine the role of the identified polymorphisms in the development of DTC and their possible use in the clinical practice. Copyright © 2013 by The Endocrine Society.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
DOIs
Publication statusPublished - 1 Oct 2013

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