Genetics of recurrent miscarriage and fetal loss

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57 Citations (Scopus)

Abstract

Despite years of research, miscarriage, particularly when recurrent, continues to pose a medical challenge. An embryo chromosomal error is responsible for 50-60% of recurrent cases; however, up to 30-50% remains an enigma. Successful pregnancy involves different maternal physiologic changes and certain complex interactions between the fetus and the mother by cytokines, angiogenic mediators and hormones. To date, research lines have focused on genetic and epigenetic polymorphisms related mainly to immune response and inflammatory mediators, and have yielded a significant relationship between recurrent miscarriage and immune mechanisms. Thus, unknown causes of miscarriage could be due to an immune imbalance induced by T-helper Th1/Th2/Th17 cytokines and regulatory T cells. Furthermore, these genes and mediators have long been suspected of being blood markers for the clinical diagnosis and management of miscarriage; however, more evidence is required for them to be included in medical practice and obstetric guidelines.

Original languageEnglish
Pages (from-to)11-25
Number of pages15
JournalBest Practice and Research in Clinical Obstetrics and Gynaecology
Volume42
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Abortion, Habitual/genetics
  • Chromosome Aberrations
  • Chromosome Disorders/genetics
  • Female
  • Fetus
  • Humans
  • Polymorphism, Genetic
  • Pregnancy

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