TY - JOUR
T1 - Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits
AU - Ortega, Francisco J.
AU - Agüera, Zaida
AU - Sabater, Mònica
AU - Moreno-Navarrete, José M.
AU - Alonso-Ledesma, Isabel
AU - Xifra, Gemma
AU - Botas, Patricia
AU - Delgado, Elías
AU - Jimenez-Murcia, Susana
AU - Fernández-García, José C.
AU - Tinahones, Francisco J.
AU - Baños, Rosa M.
AU - Botella, Cristina
AU - de la Torre, Rafael
AU - Frühbeck, Gema
AU - Rodrigüez, Amaia
AU - Estivill, Xavier
AU - Casanueva, Felipe
AU - Ricart, Wifredo
AU - Fernández-Aranda, Fernando
AU - Fernández-Real, José M.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: Changes in genetic variations affecting the taste receptor, type 2, member 38 (TAS2R38) may identify the interacting mechanism leading to obesity and potential associations with proteins partaking in innate immunity, such as surfactant protein D (SPD) and mannan-binding lectin (MBL). Methods and results: We evaluated haplotypes of the bitter-taste receptor TAS2R38 in an identification sample of 210 women in different weight conditions, including anorexia nervosa and obesity. The association with SPD and MBL was tested in an independent sample picturing general population (n = 534). The relationship with obesity was validated in an extended final sample of 1319 participants. In the sample comprised of women in extreme weight conditions, increased obesity was identified in AVI/AVI subjects (OR = 2.5 [1.06–6.11], p = 0.035). In the sample picturing general population, increased SPD and MBL concentrations were found in nonsmoking AVI carriers. In this cohort, smoking and obesity blunted associations between TAS2R38 haplotypes and SPD and MBL. In the extended sample, the association of AVI/AVI haplotypes with increased obesity was also identified (OR = 1.4 [0.99/1.85], p = 0.049), being more robust in subjects aged <40 years (OR = 1.9 [1.06/3.42], p = 0.031). Conclusion: Current data reinforce the impact of TAS2R38 gene on phenotypic and clinical outputs affecting obesity, showing significant associations with extreme weight conditions (i.e., obesity and anorexia nervosa), and changes in both olfactory capacity and immune traits.
AB - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: Changes in genetic variations affecting the taste receptor, type 2, member 38 (TAS2R38) may identify the interacting mechanism leading to obesity and potential associations with proteins partaking in innate immunity, such as surfactant protein D (SPD) and mannan-binding lectin (MBL). Methods and results: We evaluated haplotypes of the bitter-taste receptor TAS2R38 in an identification sample of 210 women in different weight conditions, including anorexia nervosa and obesity. The association with SPD and MBL was tested in an independent sample picturing general population (n = 534). The relationship with obesity was validated in an extended final sample of 1319 participants. In the sample comprised of women in extreme weight conditions, increased obesity was identified in AVI/AVI subjects (OR = 2.5 [1.06–6.11], p = 0.035). In the sample picturing general population, increased SPD and MBL concentrations were found in nonsmoking AVI carriers. In this cohort, smoking and obesity blunted associations between TAS2R38 haplotypes and SPD and MBL. In the extended sample, the association of AVI/AVI haplotypes with increased obesity was also identified (OR = 1.4 [0.99/1.85], p = 0.049), being more robust in subjects aged <40 years (OR = 1.9 [1.06/3.42], p = 0.031). Conclusion: Current data reinforce the impact of TAS2R38 gene on phenotypic and clinical outputs affecting obesity, showing significant associations with extreme weight conditions (i.e., obesity and anorexia nervosa), and changes in both olfactory capacity and immune traits.
KW - Haplotypes
KW - Immune system
KW - Mannose-binding lectin
KW - Metabolism
KW - Obesity
KW - Surfactant protein D
KW - Taste receptor type 2 member 38
U2 - 10.1002/mnfr.201500804
DO - 10.1002/mnfr.201500804
M3 - Article
SN - 1613-4125
VL - 60
SP - 1673
EP - 1683
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 7
ER -
