Genetic diversity of rhinoviruses detected at a tertiary hospital in Catalonia (Spain) during the 2014-2017 seasons

Cristina Andrés, Paula Peremiquel-Trillas, Laura Gimferrer, Anna Isern, Maria Piñana, José Ángel Rodrigo-Pendás, Maria Gema Codina, María Del Carmen Martín, Francisco Fuentes, Susana Rubio, Magda Campins-Martí, Tomàs Pumarola, Andrés Antón

Research output: Contribution to journalArticleResearch

1 Citation (Scopus)

Abstract

© 2018 Future Medicine Ltd. Aim: To describe the genetic diversity of rhinovirus (RV) from patients attended at a tertiary hospital in Barcelona (Spain) from October 2014 to May 2017. Methods: RV detection was performed by real-time multiplex RT-PCR. A specific real-time quantitive retrotranscription PCR (qRT-PCR) was carried out to select those samples (Ct < 35) for molecular characterization based on partial VP4/2 protein. Results: Phylogenetic characterization revealed proportions of 63% RV-A, 6% RV-B and 31% RV-C (119 different types). RV-A circulated throughout all the study period, with a minor circulation during winter, just when RV-C prevailed. Differences between age medians by RV-specie were reported. Conclusion: The large genetic diversity of RV detected in our area is described here. The variable cocirculation of multiple RV types is also reported, showing differences by age.
Original languageEnglish
Pages (from-to)1565-1573
JournalFuture Microbiology
Volume13
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • evolution
  • genetic diversity
  • mild respiratory diseases
  • molecular epidemiology
  • pediatric patients
  • respiratory tract infection
  • respiratory virus
  • rhinovirus
  • RV circulation
  • surveillance

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