Genetic damage in chronic renal failure patients is associated with the glomerular filtration rate index

Silvia Berenice Sandoval, Elitsa Stoyanova, Elisabet Coll, Susana Pastor, Joselyn Reyes, Enrique Andrés, José Ballarin, Noel Xamena, Ricard Marcos

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Abstract

Chronic renal failure (CRF) patients are considered to present genomic instability and, as a consequence, elevated levels of genetic damage. An open question is whether this damage is related to the stage of the pathology. To determine the background levels of genetic damage, a large population of 258 Caucasian adults (201 CRF patients and 57 controls) was analysed using the micronucleus (MN) assay. The frequency of MN in CRF patients was significantly higher than in controls and correlated with the progression of the disease, according to the glomerular filtration rate. In addition, a significant association was observed between genetic damage and serum creatinine levels. Genetic damage, measured as frequency of MN, increases when renal function decreases. The fact that an increased level of MN is already observed in patients' Stage 2 seems to indicate a genetic predisposition on these patients. Nevertheless, part of the observed damage can be attributed to the uraemic state itself. © The Author 2010. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved.
Original languageEnglish
Pages (from-to)603-608
JournalMutagenesis
Volume25
Issue number6
DOIs
Publication statusPublished - 1 Nov 2010

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