Genetic analysis of SLCIIAI polymorphisms in multiple sclerosis patients

Manuel Comabella; Laura Altet; Francesc Peris; Pablo Villoslada; Armand Sánchez; Xavier Montalban

doi:10.1191/1352458504ms1097oa

Genetic analysis of SLCIIAI polymorphisms in multiple sclerosis patients

Manuel Comabella, Laura Altet, Francesc Peris, Pablo Villoslada, Armand Sánchez, Xavier Montalban

Department of Animal and Food Science

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLCIIA1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and Crohn's disease. We investigated SLC11A1 gene as a candidate gene for genetic susceptibility to multiple sclerosis (MS) in our population. Four SLC11A1 gene polymorphisms (5′ GT repeat, D543N, 1729 + 55del4 and 1729 + 271del4) were analysed in a case-control study of 195 patients with MS and 125 control subjects. We found no evidence of association between SLC11A1 polymorphisms and MS susceptibility in the Spanish population. © Arnold 2004.

Original language	English
Pages (from-to)	618-620
Journal	Multiple Sclerosis
Volume	10
Issue number	6
DOIs	https://doi.org/10.1191/1352458504ms1097oa
Publication status	Published - 1 Dec 2004

Keywords

Association studies
Autoimmune diseases
Candidate genes
Genetic susceptibility
Multiple sclerosis
Polymorphisms

Access to Document

10.1191/1352458504ms1097oa

Fingerprint Dive into the research topics of 'Genetic analysis of SLCIIAI polymorphisms in multiple sclerosis patients'. Together they form a unique fingerprint.

Cite this

@article{2bfd3b042b974804b24cc089dc4c07b6,

title = "Genetic analysis of SLCIIAI polymorphisms in multiple sclerosis patients",

abstract = "Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLCIIA1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and Crohn's disease. We investigated SLC11A1 gene as a candidate gene for genetic susceptibility to multiple sclerosis (MS) in our population. Four SLC11A1 gene polymorphisms (5′ GT repeat, D543N, 1729 + 55del4 and 1729 + 271del4) were analysed in a case-control study of 195 patients with MS and 125 control subjects. We found no evidence of association between SLC11A1 polymorphisms and MS susceptibility in the Spanish population. {\textcopyright} Arnold 2004.",

keywords = "Association studies, Autoimmune diseases, Candidate genes, Genetic susceptibility, Multiple sclerosis, Polymorphisms",

author = "Manuel Comabella and Laura Altet and Francesc Peris and Pablo Villoslada and Armand S{\'a}nchez and Xavier Montalban",

year = "2004",

month = dec,

day = "1",

doi = "10.1191/1352458504ms1097oa",

language = "English",

volume = "10",

pages = "618--620",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

number = "6",

}

TY - JOUR

T1 - Genetic analysis of SLCIIAI polymorphisms in multiple sclerosis patients

AU - Comabella, Manuel

AU - Altet, Laura

AU - Peris, Francesc

AU - Villoslada, Pablo

AU - Sánchez, Armand

AU - Montalban, Xavier

PY - 2004/12/1

Y1 - 2004/12/1

N2 - Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLCIIA1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and Crohn's disease. We investigated SLC11A1 gene as a candidate gene for genetic susceptibility to multiple sclerosis (MS) in our population. Four SLC11A1 gene polymorphisms (5′ GT repeat, D543N, 1729 + 55del4 and 1729 + 271del4) were analysed in a case-control study of 195 patients with MS and 125 control subjects. We found no evidence of association between SLC11A1 polymorphisms and MS susceptibility in the Spanish population. © Arnold 2004.

AB - Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLCIIA1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and Crohn's disease. We investigated SLC11A1 gene as a candidate gene for genetic susceptibility to multiple sclerosis (MS) in our population. Four SLC11A1 gene polymorphisms (5′ GT repeat, D543N, 1729 + 55del4 and 1729 + 271del4) were analysed in a case-control study of 195 patients with MS and 125 control subjects. We found no evidence of association between SLC11A1 polymorphisms and MS susceptibility in the Spanish population. © Arnold 2004.

KW - Association studies

KW - Autoimmune diseases

KW - Candidate genes

KW - Genetic susceptibility

KW - Multiple sclerosis

KW - Polymorphisms

U2 - 10.1191/1352458504ms1097oa

DO - 10.1191/1352458504ms1097oa

M3 - Article

VL - 10

SP - 618

EP - 620

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 6

ER -