Abstract
Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLCIIA1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and Crohn's disease. We investigated SLC11A1 gene as a candidate gene for genetic susceptibility to multiple sclerosis (MS) in our population. Four SLC11A1 gene polymorphisms (5′ GT repeat, D543N, 1729 + 55del4 and 1729 + 271del4) were analysed in a case-control study of 195 patients with MS and 125 control subjects. We found no evidence of association between SLC11A1 polymorphisms and MS susceptibility in the Spanish population. © Arnold 2004.
Original language | English |
---|---|
Pages (from-to) | 618-620 |
Journal | Multiple Sclerosis |
Volume | 10 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Dec 2004 |
Keywords
- Association studies
- Autoimmune diseases
- Candidate genes
- Genetic susceptibility
- Multiple sclerosis
- Polymorphisms