Genetic analysis of SLCIIAI polymorphisms in multiple sclerosis patients

Manuel Comabella, Laura Altet, Francesc Peris, Pablo Villoslada, Armand Sánchez, Xavier Montalban

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7 Citations (Scopus)

Abstract

Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLCIIA1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and Crohn's disease. We investigated SLC11A1 gene as a candidate gene for genetic susceptibility to multiple sclerosis (MS) in our population. Four SLC11A1 gene polymorphisms (5′ GT repeat, D543N, 1729 + 55del4 and 1729 + 271del4) were analysed in a case-control study of 195 patients with MS and 125 control subjects. We found no evidence of association between SLC11A1 polymorphisms and MS susceptibility in the Spanish population. © Arnold 2004.
Original languageEnglish
Pages (from-to)618-620
JournalMultiple Sclerosis
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Dec 2004

Keywords

  • Association studies
  • Autoimmune diseases
  • Candidate genes
  • Genetic susceptibility
  • Multiple sclerosis
  • Polymorphisms

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