Gender-specific neuroimmunoendocrine response to treadmill exercise in 3xTg-AD mice

Lydia Giménez-Llort, Yoelvis García, Karla Buccieri, Susana Revilla, Cristina Suol, Rosa Cristofol, Coral Sanfeliu

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77 Citations (Scopus)


The 3xTg-AD mouse develops a progressive Alzheimer's disease- (AD-) like brain pathology that causes cognitive- and neuropsychiatric-like symptoms of dementia. Since its neuroimmunoendocrine axis is likewise impaired, this mouse is also useful for modelling complex age-related neurodegeneration. This study analyzed behavioral, physiological, neurochemical, pathological and immunoendocrine alterations in male and female 3xTg-AD mice and assayed the effects of a short therapy of forced physical exercise at the moderate pathology stage of 6 months of age. Gender effects were observed in most AD-related pathology and dysfunctions. Five weeks of treadmill training produced beneficial effects, such as the reduction of brain oxidative stress and GABA-A receptor dysfunction in males and improvement of sensorimotor function in females. In both sexes, exercise decreased the brain amyloid β42/40 ratio levels. The results highlight the importance of analyzing experimental therapies in both mouse model genders in order to improve our understanding of the disease and develop more appropriate therapies. Copyright © 2010 Lydia Gimnez-Llort et al.
Original languageEnglish
Article number128354
JournalInternational Journal of Alzheimer's Disease
Publication statusPublished - 22 Nov 2010


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