Gastrogastric reflexes regulating gastric tone and their relationship to perception

Nicola Villanova, Fernando Azpiroz, Juan R. Malagelada

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31 Citations (Scopus)


Our aim was to investigate in humans the gastrogastric reflexes that regulate gastric tone and their relationship to perception. In nine healthy subjects, liquid distension (in 100-ml stops), warm stimuli (in 3°C increments), and cold stimuli (in 6°C decrements) were randomly applied in the stomach for 3 rain at 8-min intervals. Gastric tone was measured as isobaric volume changes of air by a barostat, and perception was scored by a graded (0-6) questionnaire. Liquid accommodation produced an additional expansion of isobaric air maintained by the barostat (51 ± 13 ml with 100 ml of liquid filling, P < 0.05), but this effect became inconsistent with further filling. An accommodation-like reflex was best evidenced by warm stimulation below the discomfort threshold (58 ± 13 ml relaxation at 47 ± 1°C, P < 0.05). By contrast, cooling below discomfort induced a reflex contraction (-62 ± 22 ml change at 18 ± 2°C, P < 0.05). In conclusion, gastric tone, i.e., accommodation and contraction, is modulated by a net of reflexes that arise from the proper wall of the stomach below the discomfort threshold.
Original languageEnglish
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number2 36-2
Publication statusPublished - 13 Oct 1997


  • Gastric accommodation
  • Gastric barostat
  • Gastric distension
  • Gastric sensitivity
  • Thermal stimulation


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