GAL <inf>3</inf> receptor KO mice exhibit an anxietylike phenotype

Susanne M. Brunner, Aitak Farzi, Felix Locker, Barbara S. Holub, Meinrad Drexel, Florian Reichmann, Andreas A. Lang, Johannes A. Mayr, Jorge J. Vilches, Xavier Navarro, Roland Lang, Günther Sperk, Peter Holzer, Barbara Kofler

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Abstract

The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems. It is a modulator of various physiological and pathological processes, and it mediates its effects via three G protein-coupled receptors (GAL 1-3 receptors). A role for GAL as a modulator of mood and anxiety was suggested, because GAL and its receptors are highly expressed in limbic brain structures of rodents. In recent years, numerous studies of animal models have suggested an involvement of GAL and GAL1 and GAL2 receptors in anxiety-and depression-related behavior. However, to date, there is sparse literature implicating GAL3 receptors in behavioral functions. Therefore, we studied the behavior of GAL3 receptor-deficient (GAL 3- KO) mice to elucidate whether GAL3 receptors are involved in mediating behavior-associated actions of GAL. The GAL 3- KO mouse line exhibited normal breeding and physical development. In addition to behavioral tests, phenotypic characterization included analysis of hematology, amino acid profiles, metabolism, and sudomotor function. In contrast to WT littermates, male GAL 3- KO mice exhibited an anxietylike phenotype in the elevated plus maze, open field, and light/dark box tests, and they were less socially affiliated than WT animals to a stranger mouse in a social interaction test. In conclusion, our data suggest involvement of GAL3 receptors in GAL-mediated effects on mood, anxiety, and behavior, making it a possible target for alternative treatment strategies for mood disorders.
Original languageEnglish
Pages (from-to)7138-7143
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
DOIs
Publication statusPublished - 13 May 2014

Keywords

  • Galanin receptor
  • Gcat variant 2
  • Serotonin

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