Further evidence for preoperative chemoradiotherapy and transanal endoscopic surgery (TEM) in T2-3s,N0,M0 rectal cancer

C. Pericay, X. Serra-Aracil, J. Ocaña-Rojas, L. Mora-López, E. Dotor, A. Casalots, A. Pisa, E. Saigí

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

© 2015, Federación de Sociedades Españolas de Oncología (FESEO). Purpose: Preoperative chemoradiotherapy and local excision via transanal endoscopic surgery (TEM) in T2–3s,N0,M0 rectal cancer achieve promising results in selected patients. We describe our long-term follow-up experience with this combination, and evaluate complete clinical and pathological responses, local recurrence and overall survival. Methods: The prospective observational follow-up study carried out since 2007. Out of 476 consecutive patients treated with TEM, we selected those with adenocarcinoma of low or moderate grade of differentiation, clinical stages T2-superficial T3,N0,M0, who refused radical surgery. Preoperative chemoradiotherapy comprised 5-fluorouracil or capecitabine combined with radiotherapy at a dose of 50.4 Gy. TEM was performed after 8 weeks. Complications were recorded and long-term follow-up was conducted. Results: Fifteen patients undergoing preoperative chemoradiotherapy and TEM (median age 76 years, 95 % CI 70.3–80.4, and median follow-up 38 months, 95 % CI 20–44) were studied. No local recurrence was observed, and only one patient (6.7 %) presented systemic relapse. The overall survival was 76 %. Complete clinical response was achieved in seven patients (46.7 %) and complete pathological response in four (26.7 %). With regard to toxicity associated with neoadjuvant treatment, four patients (26.7 %) developed grade 3 adverse effects; no grade 4 or 5 adverse effects were observed. There was no postoperative mortality. Conclusions: The results of our study, with a response rate of 26.7 % and without local relapse, support the treatment of T2–3s,N0,M0 of rectal cancer with preoperative chemoradiotherapy and local excision (TEM).
Original languageEnglish
Pages (from-to)666-671
JournalClinical and Translational Oncology
Volume18
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016

Keywords

  • Preoperative chemoradioterapy
  • Rectal cancer
  • TEM

Fingerprint

Dive into the research topics of 'Further evidence for preoperative chemoradiotherapy and transanal endoscopic surgery (TEM) in T2-3s,N0,M0 rectal cancer'. Together they form a unique fingerprint.

Cite this