Functionalized azobenzene platinum(II) complexes as putative anticancer compounds

Katia G. Samper, Julia Lorenzo, Mercè Capdevila, Òscar Palacios*, Pau Bayón

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The synthesis and characterization of four platinum(II) complexes using azobenzenes conveniently functionalized as ligands has been carried out. The characteristic photochemical behavior of the complexes due to the presence of azobenzene-type ligands and the role of the ligands in the activation of the complexes has been studied. Their promising cytotoxicity observed in HeLa cells prompted us to study the mechanism of action of these complexes as cytostatic agents. The interaction of the compounds with DNA, studied by circular dichroism, revealed a differential activity of the Pt(II) complexes upon irradiation. The intercalation abilities of the complexes as well as their reactivity with common proteins present in the blood stream allows to confirm some of the compounds obtained as good anticancer candidates.

Original languageEnglish
JournalJournal of Biological Inorganic Chemistry
DOIs
Publication statusAccepted in press - 2021

Keywords

  • Antitumor drug
  • Azobenzene
  • Cisplatin resistance
  • Platinum complex

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