Functionalized azobenzene platinum(II) complexes as putative anticancer compounds

Katia G. Samper; Julia Lorenzo; Mercè Capdevila; Òscar Palacios; Pau Bayón

doi:10.1007/s00775-021-01865-9

Functionalized azobenzene platinum(II) complexes as putative anticancer compounds

Katia G. Samper, Julia Lorenzo, Mercè Capdevila, Òscar Palacios^*, Pau Bayón

^*Corresponding author for this work

Universitat Autònoma de Barcelona (UAB)

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

The synthesis and characterization of four platinum(II) complexes using azobenzenes conveniently functionalized as ligands has been carried out. The characteristic photochemical behavior of the complexes due to the presence of azobenzene-type ligands and the role of the ligands in the activation of the complexes has been studied. Their promising cytotoxicity observed in HeLa cells prompted us to study the mechanism of action of these complexes as cytostatic agents. The interaction of the compounds with DNA, studied by circular dichroism, revealed a differential activity of the Pt(II) complexes upon irradiation. The intercalation abilities of the complexes as well as their reactivity with common proteins present in the blood stream allows to confirm some of the compounds obtained as good anticancer candidates.

Original language	English
Journal	Journal of Biological Inorganic Chemistry
DOIs	https://doi.org/10.1007/s00775-021-01865-9
Publication status	Accepted in press - 2021

Keywords

Antitumor drug
Azobenzene
Cisplatin resistance
Platinum complex

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title = "Functionalized azobenzene platinum(II) complexes as putative anticancer compounds",

abstract = "The synthesis and characterization of four platinum(II) complexes using azobenzenes conveniently functionalized as ligands has been carried out. The characteristic photochemical behavior of the complexes due to the presence of azobenzene-type ligands and the role of the ligands in the activation of the complexes has been studied. Their promising cytotoxicity observed in HeLa cells prompted us to study the mechanism of action of these complexes as cytostatic agents. The interaction of the compounds with DNA, studied by circular dichroism, revealed a differential activity of the Pt(II) complexes upon irradiation. The intercalation abilities of the complexes as well as their reactivity with common proteins present in the blood stream allows to confirm some of the compounds obtained as good anticancer candidates.",

keywords = "Antitumor drug, Azobenzene, Cisplatin resistance, Platinum complex",

author = "Samper, {Katia G.} and Julia Lorenzo and Merc{\`e} Capdevila and {\`O}scar Palacios and Pau Bay{\'o}n",

year = "2021",

doi = "10.1007/s00775-021-01865-9",

language = "English",

journal = "Journal of Biological Inorganic Chemistry",

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T1 - Functionalized azobenzene platinum(II) complexes as putative anticancer compounds

AU - Samper, Katia G.

AU - Lorenzo, Julia

AU - Capdevila, Mercè

AU - Palacios, Òscar

AU - Bayón, Pau

PY - 2021

Y1 - 2021

N2 - The synthesis and characterization of four platinum(II) complexes using azobenzenes conveniently functionalized as ligands has been carried out. The characteristic photochemical behavior of the complexes due to the presence of azobenzene-type ligands and the role of the ligands in the activation of the complexes has been studied. Their promising cytotoxicity observed in HeLa cells prompted us to study the mechanism of action of these complexes as cytostatic agents. The interaction of the compounds with DNA, studied by circular dichroism, revealed a differential activity of the Pt(II) complexes upon irradiation. The intercalation abilities of the complexes as well as their reactivity with common proteins present in the blood stream allows to confirm some of the compounds obtained as good anticancer candidates.

AB - The synthesis and characterization of four platinum(II) complexes using azobenzenes conveniently functionalized as ligands has been carried out. The characteristic photochemical behavior of the complexes due to the presence of azobenzene-type ligands and the role of the ligands in the activation of the complexes has been studied. Their promising cytotoxicity observed in HeLa cells prompted us to study the mechanism of action of these complexes as cytostatic agents. The interaction of the compounds with DNA, studied by circular dichroism, revealed a differential activity of the Pt(II) complexes upon irradiation. The intercalation abilities of the complexes as well as their reactivity with common proteins present in the blood stream allows to confirm some of the compounds obtained as good anticancer candidates.

KW - Antitumor drug

KW - Azobenzene

KW - Cisplatin resistance

KW - Platinum complex

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U2 - 10.1007/s00775-021-01865-9

DO - 10.1007/s00775-021-01865-9

M3 - Article

C2 - 33934217

AN - SCOPUS:85105378302

SN - 0949-8257

JO - Journal of Biological Inorganic Chemistry

JF - Journal of Biological Inorganic Chemistry

ER -

Functionalized azobenzene platinum(II) complexes as putative anticancer compounds

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Keywords

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