Abstract
Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.
Original language | English |
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Pages (from-to) | 1742-1747 |
Number of pages | 6 |
Journal | Advanced Materials |
Volume | 24 |
Issue number | 13 |
DOIs | |
Publication status | Published - 3 Apr 2012 |
Keywords
- cell therapy
- nanomedicine
- nanopills
- protein particles
- recombinant proteins