Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies

Esther Vázquez; José L. Corchero; Joan F. Burgueño; Joaquin Seras-Franzoso; Ana Kosoy; Ramon Bosser; Rosa Mendoza; Joan Marc Martínez-Láinez; Ursula Rinas; Ester Fernández; Luis Ruiz-Avila; Elena García-Fruitõs; Antonio Villaverde

doi:10.1002/adma.201290071

Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies

Esther Vázquez, José L. Corchero, Joan F. Burgueño, Joaquin Seras-Franzoso, Ana Kosoy, Ramon Bosser, Rosa Mendoza, Joan Marc Martínez-Láinez, Ursula Rinas, Ester Fernández, Luis Ruiz-Avila, Elena García-Fruitõs^*, Antonio Villaverde

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

66 Citations (Scopus)

Abstract

Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.

Original language	English
Pages (from-to)	1742-1747
Number of pages	6
Journal	Advanced Materials
Volume	24
Issue number	13
DOIs	https://doi.org/10.1002/adma.201290071 https://doi.org/10.1002/adma.201104330
Publication status	Published - 3 Apr 2012

Keywords

cell therapy
nanomedicine
nanopills
protein particles
recombinant proteins

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Vázquez, E., Corchero, J. L., Burgueño, J. F., Seras-Franzoso, J., Kosoy, A., Bosser, R., Mendoza, R., Martínez-Láinez, J. M., Rinas, U., Fernández, E., Ruiz-Avila, L., García-Fruitõs, E., & Villaverde, A. (2012). Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies. Advanced Materials, 24(13), 1742-1747. https://doi.org/10.1002/adma.201290071, https://doi.org/10.1002/adma.201104330

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abstract = "Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.",

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Vázquez, E , Corchero, JL, Burgueño, JF, Seras-Franzoso, J, Kosoy, A, Bosser, R, Mendoza, R, Martínez-Láinez, JM, Rinas, U, Fernández, E, Ruiz-Avila, L, García-Fruitõs, E & Villaverde, A 2012, 'Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies', Advanced Materials, vol. 24, no. 13, pp. 1742-1747. https://doi.org/10.1002/adma.201290071, https://doi.org/10.1002/adma.201104330

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T1 - Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies

AU - Vázquez, Esther

AU - Corchero, José L.

AU - Burgueño, Joan F.

AU - Seras-Franzoso, Joaquin

AU - Kosoy, Ana

AU - Bosser, Ramon

AU - Mendoza, Rosa

AU - Martínez-Láinez, Joan Marc

AU - Rinas, Ursula

AU - Fernández, Ester

AU - Ruiz-Avila, Luis

AU - García-Fruitõs, Elena

AU - Villaverde, Antonio

PY - 2012/4/3

Y1 - 2012/4/3

N2 - Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.

AB - Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.

KW - cell therapy

KW - nanomedicine

KW - nanopills

KW - protein particles

KW - recombinant proteins

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DO - 10.1002/adma.201290071

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SN - 0935-9648

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SP - 1742

EP - 1747

JO - Advanced Materials

JF - Advanced Materials

IS - 13

ER -

Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies

Abstract

Keywords

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