Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.

Original languageEnglish
Pages (from-to)1742-1747
Number of pages6
JournalAdvanced Materials
Issue number13
Publication statusPublished - 3 Apr 2012


  • cell therapy
  • nanomedicine
  • nanopills
  • protein particles
  • recombinant proteins


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