Functional Examination of the Upper and Lower Airways in Asthma and Respiratory Allergic Diseases: Considerations in the Post-SARS-CoV-2 Era

J. M. Olaguibel, I Alobid, Alvarez Puebla M, A. Crespo-Lessmann, Dominguez Ortega J, F. Garcia-Rio, A. Izquierdo-Dominguez, J. Mullol, V Plaza, S. Quirce, M. J. Rojas-Lechuga, M. Valvere-Monge, J. Sastre

Research output: Contribution to journalReview articleResearchpeer-review

13 Citations (Web of Science)

Abstract

Airway examination procedures can potentially transmit infectious diseases to patients and to the health care professionals who
perform them via various mechanisms. The COVID-19 pandemic has halted most of the activity of the clinics and laboratories involved in
assessment of lung and nasal function, and clear recommendations in this regard have been made. Today, we still do not know for sure
what its consequences will be in the short or long term, since important gaps remain in our knowledge of aspects as fundamental as virus
transmission mechanisms, pathophysiology, immune response, and diagnosis.
In this review, we study the examination techniques used to assess patients with respiratory allergy, asthma, and associated diseases
during this period and highlight their possible advantages and disadvantages. Therefore, we focus on exploring the entire upper and lower
airways, from the perspective of the safety of both health professionals and patients and their specific characteristics. We also analyze the
intrinsic value of these interventions in terms of diagnosis and patient management.
The changing situation of COVID-19 may mean that some of the assertions presented in this review will have to be modified in the future.
While we seek to ensure a consistently broad approach, some differences in operational details may apply owing to local regulations
Original languageEnglish
Pages (from-to)17-35
Number of pages19
JournalJournal of Investigational Allergology and Clinical Immunology
Volume31
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • Allergic rhinitis
  • Asthma
  • Bronchial challenge
  • Inflammatory biomarkers
  • Lung function tests
  • Upper airway examination

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