From suspicion to action: The chemical conjunctivitis and silver nitrate connexion example in Brazilian hospitals

Berta Monica Napchan, Raquel Pinheiro Morales, Marisa Lima Carvalho, Keliane Vasconcellos Cunha, Albert Figueras

    Research output: Contribution to journalArticleResearchpeer-review

    9 Citations (Scopus)

    Abstract

    Background: During the 20th century, silver nitrate (SN) eye drops instillation to newborns had been the best prophylaxis against ophthalmia neonatorum (ON) caused by Neisseria gonorrheae, the most frequent cause of ocular infections leading to blindness. At present, this treatment has been questioned because there is a growing prevalence of other pathogens such as Chlamydia trachomatis, and SN is associated with chemical conjunctivitis (ChC). In addition, SN could present some conservation problems in tropical climates. Among other alternative drugs, 2.5% povidone-iodine has a proven efficacy, not only against Neisseria, but also against Chlamydia, has no conservation problems, has not been associated with ChC and is cheap. Methods: The recently created Setor de Farmacovigilância (SF) of the São Paulo State in Brazil has created a pharmacovigilance network of 11 big public hospitals. During a periodical signal searching process, the SF found a cluster of 33 ChC reports from one of the network hospitals. Results: The problem was discussed with the remaining participant hospitals and this signal was used as a way to strengthen the network. Thirteen months later, 622 ChC reports were received from six hospitals. Discussion: Thus, this well-known side-effect in the literature was highlighted as a 'real' problem in Brazil, and some participant hospitals began a discussion period together with the delivery and newborn care professionals in order to switch SN by povidone-iodine. This is an example of both, how a simple pharmacovigilance exercice could improve the implication of health professionals with their own therapeutic problems and how a pharmacovigilance network could be strengthened. Copyright © 2004 John Wiley & Sons, Ltd.
    Original languageEnglish
    Pages (from-to)555-559
    JournalPharmacoepidemiology and Drug Safety
    Volume14
    Issue number8
    DOIs
    Publication statusPublished - 1 Aug 2005

    Keywords

    • Knowledge
    • Newborn
    • Ophtalmia neonatorum
    • Pharmacovigilance

    Fingerprint Dive into the research topics of 'From suspicion to action: The chemical conjunctivitis and silver nitrate connexion example in Brazilian hospitals'. Together they form a unique fingerprint.

    Cite this