Starting from a common, easily available, enantiopure monoketal of p-benzoquinone, the synthesis of a large number of cyclohexane chirons has been achieved. The first synthesis of (+)-rengyolone and (+)- and (-)-menisdaurilide has been performed from one of these new building blocks. The wide variety of functional groups of this series of chirons makes them useful for subsequent synthetic processes. © 2003 Elsevier Science Ltd. All rights reserved.
|Publication status||Published - 18 Jul 2003|
Busqué, F., Cantó, M., De March, P., Figueredo, M., Font, J., & Rodríguez, S. (2003). From p-benzoquinone to cyclohexane chirons: First asymmetric synthesis of (+)-rengyolone and (+)- and (-)-menisdaurilide. Tetrahedron Asymmetry, 14(14), 2021-2032. https://doi.org/10.1016/S0957-4166(03)00357-4