Frequency and prognostic significance of additional cytogenetic abnormalities to the Philadelphia chromosome in young and older adults with acute lymphoblastic leukemia

Cristina Motlló, Josep Maria Ribera, Mireia Morgades, Isabel Granada, Pau Montesinos, Santiago Mercadal, José González-Campos, María José Moreno, Pere Barba, Marta Cervera, Manuel Barrios, Andrés Novo, Teresa Bernal, Jesús María Hernández-Rivas, Eugenia Abella, María Luz Amigo, Mar Tormo, Rodrigo Martino, Esperanza Lavilla, Juan BerguaAlfons Serrano, Daniel García-Belmonte, Ramon Guàrdia, Javier Grau, Evarist Feliu

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5 Citations (Scopus)

Abstract

© 2017 Informa UK Limited, trading as Taylor & Francis Group. About 25–35% of adult patients with acute lymphoblastic leukemia show the Philadelphia (Ph) chromosome. Few series have evaluated the prognosis of additional cytogenetic alterations (ACA) to the Ph chromosome. We analyzed the frequency, type and prognostic significance ofACA in adults (18–60 years) treated in the ALL-Ph-08 trial. Fifty-two out of 74 patients (70%) showed ACA and 19 (26%) presented monosomies associated with t(9;22) (monosomal karyotype, MK). Similar complete response (CR) rate, CR duration, overall survival and event-free survival (EFS) were observed in patients with or without ACA, but patients with MK showed shorter CR duration and EFS than the remaining. On multivariate analysis, the only variable with prognostic impact for CR duration and EFS was the presence of MK (p =.003 and p =.036, respectively). Although ACA associated with the Ph chromosome are frequent, only monosomies were associated with poor prognosis in this group of patients.
Original languageEnglish
Pages (from-to)146-154
JournalLeukemia and Lymphoma
Volume59
Issue number1
DOIs
Publication statusPublished - 2 Jan 2018

Keywords

  • Acute lymphoblastic leukemia
  • Philadelphia chromosome
  • additional cytogenetic alterations
  • monosomies
  • prognosis

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