Fragile sites, chromosome evolution, and human neoplasia

Rosa Miró, Inmaculada Concepción Clemente, Carmen Fuster, José Egozcue

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65 Citations (Scopus)


In a study of the possible relationship between human fragile sites, chromosomal rearrangements related to neoplasia, and chromosome regions involved in evolutionary changes, we have found that 17 fragile sites related to cancer, 15 fragile sites not related to cancer, and 17 non-fragile regions also related to human malignancy correspond or are close to bands involved in rearrangements that have taken place during chromosomal evolution in primates. © 1987 Springer-Verlag.
Original languageEnglish
Pages (from-to)345-349
JournalHuman Genetics
Issue number4
Publication statusPublished - 1 Apr 1987


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