TY - JOUR
T1 - Fourier transform infrared spectroscopy (FTIR) characterization of the interaction of anti-cancer photosensitizers with dendrimers
AU - Dabrzalska, Monika
AU - Benseny-Cases, Nuria
AU - Barnadas-Rodríguez, Ramon
AU - Mignani, Serge
AU - Zablocka, Maria
AU - Majoral, Jean Pierre
AU - Bryszewska, Maria
AU - Klajnert-Maculewicz, Barbara
AU - Cladera, Josep
PY - 2016/1/1
Y1 - 2016/1/1
N2 - © 2015 Springer-Verlag Berlin Heidelberg. The systemic or local administration of a photosensitizer for photodynamic therapy is highly limited by poor selectivity, rapid deactivation and long-lasting skin toxicity due to unfavorable biodistribution. Drug delivery systems based on nanocarriers may help specific and effective delivery of photosensitizers. In the present paper, the interaction of two photosensitizers, methylene blue and rose bengal, with phosphorous cationic and anionic dendrimers as potential nanocarriers, has been characterized. A novel method is presented based on the analysis of the infrared spectra of mixtures of photosensitizer and dendrimer. The capacity of dendrimers to bind the photosensitizers has been evaluated by obtaining the corresponding binding curves. It is shown that methylene blue interacts with both cationic and anionic dendrimers, whereas rose bengal only binds to the cationic ones. Dendrimers are shown to be potential nanocarriers for a specific delivery of both photosensitizers.
AB - © 2015 Springer-Verlag Berlin Heidelberg. The systemic or local administration of a photosensitizer for photodynamic therapy is highly limited by poor selectivity, rapid deactivation and long-lasting skin toxicity due to unfavorable biodistribution. Drug delivery systems based on nanocarriers may help specific and effective delivery of photosensitizers. In the present paper, the interaction of two photosensitizers, methylene blue and rose bengal, with phosphorous cationic and anionic dendrimers as potential nanocarriers, has been characterized. A novel method is presented based on the analysis of the infrared spectra of mixtures of photosensitizer and dendrimer. The capacity of dendrimers to bind the photosensitizers has been evaluated by obtaining the corresponding binding curves. It is shown that methylene blue interacts with both cationic and anionic dendrimers, whereas rose bengal only binds to the cationic ones. Dendrimers are shown to be potential nanocarriers for a specific delivery of both photosensitizers.
KW - Dendrimer-photosensitizer interactions
KW - Infrared spectroscopy
KW - Methylene blue
KW - Phosphorus dendrimer
KW - Rose bengal
U2 - 10.1007/s00216-015-9125-0
DO - 10.1007/s00216-015-9125-0
M3 - Article
VL - 408
SP - 535
EP - 544
IS - 2
ER -
