Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

Francesco Barbero, Lorenzo Russo, Michele Vitali, Jordi Piella, Ignacio Salvo, Mireya L. Borrajo, Marti Busquets-Fité, Rita Grandori, Neus G. Bastús, Eudald Casals, Victor Puntes

    Research output: Contribution to journalReview articleResearchpeer-review

    144 Citations (Scopus)


    © 2017 Elsevier Ltd The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.
    Original languageEnglish
    Pages (from-to)52-60
    JournalSeminars in Immunology
    Publication statusPublished - 1 Dec 2017


    • Homo and Hetero-aggregation
    • Immune Response
    • Inorganic Nanoparticles
    • Nanoparticle-Protein Corona
    • Protein Corona Characterization
    • Vroman Effect


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