Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer

Eva Morales, Miquel Porta, Jesús Vioque, Tomàs López, Michelle A. Mendez, José Pumarega, Núria Malats, Maria Crous-Bou, Joy Ngo, Juli Rifà, Alfredo Carrato, Luisa Guarner, Josep M. Corominas, Francisco X. Real

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26 Citations (Scopus)


Background: No studies have investigated the relation between K-ras mutations and dietary factors in exocrine pancreatic cancer (EPC), and fewer than 10 studies have done so in other neoplasms. Patients and Methods: Incident cases of EPC were prospectively identified, and interviewed face-to-face during hospital admission. Food and nutrient intakes were measured with a food frequency questionnaire. Logistic regression was used to compare EPC cases (n = 107) with and without K-ras mutations (case-case study). Results: K-ras mutations were more common among daily consumers of milk and other dairy products than among non-daily consumers: the odds ratio adjusted by total energy, age, sex, smoking, alcohol and coffee consumption (ORa) was 5.1 (95% CI 1.1 to 24.5, p = 0.040). For all dairy products, including butter, the ORa for the medium and upper tertiles of intake were 5.4 and 11.6, respectively (p for trend = 0.023). The ORa for regular coffee drinkers further adjusted by dairy consumption was 4.7 (95% CI 1.1 to 20.7, p = 0.043). K-ras mutated cases reported a lower intake of vitamin E (ORa = 0.2, p for trend = 0.036), polyunsaturated fats and omega 3 fatty acids (ORa = 0.2; p for trend <0.03). Conclusions: Results support the hypothesis that in EPC exposure to specific dietary components or contaminants may influence the occurrence or persistence of K-ras mutations.
Original languageEnglish
Pages (from-to)641-649
JournalJournal of Epidemiology and Community Health
Issue number7
Publication statusPublished - 1 Jul 2007


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