Follow‐up after a six‐month maintenance period on naltrexone versus placebo in heroin addicts

L. SAN, G. POMAROL, J. M. PERI, J. M. OLLE, J. CAMI

    Research output: Contribution to journalArticleResearchpeer-review

    57 Citations (Scopus)

    Abstract

    Naltrexone and placebo as adjuvant treatment of opioid dependence were compared in a double‐blind, controlled clinical trial in 50 heroin addicts. The overall efficacy was assessed by the degree of treatment acceptance, percentage of relapse in heroin consumption, presence of side effects, and overall retention on naltrexone. A total of 50 patients of both sexes, aged from 18 to 30 years, who fulfilled DSM‐III‐R criteria for opioid dependence were included in the study. All patients completed detoxification with clonidine on an in‐patient basis for 2 weeks and subsequently, on an out‐patient basis, received oral naltrexone (350 mg per week) for a month. At the beginning of the second month patients were randomly allocated to treatment with naltrexone (28 patients) or placebo (22 patients) until a 6‐month treatment period in a double‐blind fashion had been completed. During the study period (1 year) all patients followed the same therapeutic schedule. Patients in both groups were comparable in terms of socio‐demographic data and toxicological history. The efficacy of naltrexone was not superior to that of placebo as there were no significant differences in acceptance of treatment, retention rates, opioid and other drug consumption, drug compliance or side effects. Copyright © 1991, Wiley Blackwell. All rights reserved
    Original languageEnglish
    Pages (from-to)983-990
    JournalBritish Journal of Addiction
    Volume86
    Issue number8
    DOIs
    Publication statusPublished - 1 Jan 1991

    Fingerprint Dive into the research topics of 'Follow‐up after a six‐month maintenance period on naltrexone versus placebo in heroin addicts'. Together they form a unique fingerprint.

  • Cite this

    SAN, L., POMAROL, G., PERI, J. M., OLLE, J. M., & CAMI, J. (1991). Follow‐up after a six‐month maintenance period on naltrexone versus placebo in heroin addicts. British Journal of Addiction, 86(8), 983-990. https://doi.org/10.1111/j.1360-0443.1991.tb01859.x