Folding of small disulfide-rich proteins: clarifying the puzzle

Joan L. Arolas, Francesc X. Aviles, Jui Yoa Chang, Salvador Ventura

Research output: Contribution to journalReview articleResearchpeer-review

124 Citations (Scopus)


The process by which small proteins fold to their native conformations has been intensively studied over the past few decades. The particular chemistry of disulfide-bond formation has facilitated the characterization of the oxidative folding of numerous small, disulfide-rich proteins with results that illustrate a high level of diversity in folding mechanisms, differing in the heterogeneity and native disulfide-bond content of their intermediates. Information from folding studies of these proteins, together with the recent structural determinations of predominant intermediates, has provided new molecular insights into oxidative folding and clarifies the major rules that govern it. © 2006 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)292-301
JournalTrends in Biochemical Sciences
Issue number5
Publication statusPublished - 1 May 2006


Dive into the research topics of 'Folding of small disulfide-rich proteins: clarifying the puzzle'. Together they form a unique fingerprint.

Cite this