Foamy macrophages and the progression of the human tuberculosis granuloma

David G. Russell, Pere Joan Cardona, Mi Jeong Kim, Sophie Allain, Frédéric Altare

Research output: Contribution to journalReview articleResearchpeer-review

427 Citations (Scopus)

Abstract

The progression of tuberculosis from a latent, subclinical infection to active disease that culminates in the transmission of infectious bacilli is determined locally at the level of the granuloma. This progression takes place even in the face of a robust immune response that, although it contains infection, is unable to eliminate the bacterium. The factors or environmental conditions that influence this progression remain to be determined. Recent advances have indicated that pathogen-induced dysregulation of host lipid synthesis and sequestration serves a critical role in this transition. The foamy macrophage seems to be a key participant in both sustaining persistent bacteria and contributing to the tissue pathology that leads to cavitation and the release of infectious bacilli.
Original languageEnglish
Pages (from-to)943-948
JournalNature Immunology
Volume10
Issue number9
DOIs
Publication statusPublished - 27 Aug 2009

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