Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial

Ramon Noguera, Rosario Altuna, Enrique Alvarez, Jose L. Ayuso, Leonardo Casais, Claudia Udina

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    19 Citations (Scopus)


    A sample of 120 patients, all of whom met DSM-III criteria for major unipolar depressive disorder, were randomly allocated to two treatment groups. Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period. No significant difference was found in antidepressant efficacy, with improvement occurring on both drugs. Important differences were found in the side-effects profile of each group, their incidence being significantly lower and tending to disappear during the course of treatment in the group of patients treated with fluoxetine. © 1991.
    Original languageEnglish
    Pages (from-to)119-124
    JournalJournal of Affective Disorders
    Issue number3
    Publication statusPublished - 1 Jan 1991


    • Antidepressant effect
    • Fluoxetine vs. clomipramine
    • Major depression
    • Side effects


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