Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial

Ramon Noguera; Rosario Altuna; Enrique Alvarez; Jose L. Ayuso; Leonardo Casais; Claudia Udina

doi:10.1016/0165-0327(91)90045-T

Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial

Ramon Noguera, Rosario Altuna, Enrique Alvarez, Jose L. Ayuso, Leonardo Casais, Claudia Udina

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Abstract

A sample of 120 patients, all of whom met DSM-III criteria for major unipolar depressive disorder, were randomly allocated to two treatment groups. Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period. No significant difference was found in antidepressant efficacy, with improvement occurring on both drugs. Important differences were found in the side-effects profile of each group, their incidence being significantly lower and tending to disappear during the course of treatment in the group of patients treated with fluoxetine. © 1991.

Original language	English
Pages (from-to)	119-124
Journal	Journal of Affective Disorders
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/0165-0327(91)90045-T
Publication status	Published - 1 Jan 1991

Keywords

Antidepressant effect
Fluoxetine vs. clomipramine
Major depression
Side effects

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10.1016/0165-0327(91)90045-T

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abstract = "A sample of 120 patients, all of whom met DSM-III criteria for major unipolar depressive disorder, were randomly allocated to two treatment groups. Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period. No significant difference was found in antidepressant efficacy, with improvement occurring on both drugs. Important differences were found in the side-effects profile of each group, their incidence being significantly lower and tending to disappear during the course of treatment in the group of patients treated with fluoxetine. {\textcopyright} 1991.",

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AU - Noguera, Ramon

AU - Altuna, Rosario

AU - Alvarez, Enrique

AU - Ayuso, Jose L.

AU - Casais, Leonardo

AU - Udina, Claudia

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AB - A sample of 120 patients, all of whom met DSM-III criteria for major unipolar depressive disorder, were randomly allocated to two treatment groups. Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period. No significant difference was found in antidepressant efficacy, with improvement occurring on both drugs. Important differences were found in the side-effects profile of each group, their incidence being significantly lower and tending to disappear during the course of treatment in the group of patients treated with fluoxetine. © 1991.

KW - Antidepressant effect

KW - Fluoxetine vs. clomipramine

KW - Major depression

KW - Side effects

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DO - 10.1016/0165-0327(91)90045-T

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JF - Journal of Affective Disorders

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ER -

Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial

Abstract

Keywords

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