Abstract
A sample of 120 patients, all of whom met DSM-III criteria for major unipolar depressive disorder, were randomly allocated to two treatment groups. Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period. No significant difference was found in antidepressant efficacy, with improvement occurring on both drugs. Important differences were found in the side-effects profile of each group, their incidence being significantly lower and tending to disappear during the course of treatment in the group of patients treated with fluoxetine. © 1991.
Original language | English |
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Pages (from-to) | 119-124 |
Journal | Journal of Affective Disorders |
Volume | 22 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 1991 |
Keywords
- Antidepressant effect
- Fluoxetine vs. clomipramine
- Major depression
- Side effects