Fluorescent Markers for Amyloid-β Detection: Computational Insights

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Abstract

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim In vivo detection of cerebral amyloid-β plaques is essential for an early diagnosis of Alzheimer′s disease. Optical imaging, which employs fluorescent markers emitting in the near-infrared range, is a growing alternative to nuclear techniques, with indisputable advantages. The rational design of amyloid markers requires optimization of both the optical and binding properties, and of their mutual interaction. In this work, the structural aspects that determine the performance of selected amyloid markers have been analyzed, focusing on the contributions offered by computational techniques.
Original languageEnglish
Pages (from-to)686-698
JournalIsrael Journal of Chemistry
Volume57
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Alzheimer′s disease
  • amyloid-beta peptides
  • density functional calculations
  • fit-induced docking
  • fluorescence imaging

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