Flumazenil prevents the anxiolytic effects of diazepam, alprazolam and adinazolam on the early acquisition of two-way active avoidance

R. M. Escorihuela; A. Fernández-Teruel; A. Zapata; J. F. Nüñez; A. Tobeńa

doi:10.1006/phrs.1993.1109

Flumazenil prevents the anxiolytic effects of diazepam, alprazolam and adinazolam on the early acquisition of two-way active avoidance

R. M. Escorihuela, A. Fernández-Teruel, A. Zapata, J. F. Nüñez, A. Tobeńa

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

The effects of diazepam (DZ, 4 mg/kg), alprazolam (ALP, 1.25 mg/kg) and adinazolam (ADIN, 6 mg/kg), as well as their interaction with the benzodiazepine receptor antagonist flumazenil (Ro15-1788), were studied on the early acquisition of two-way active (shuttlebox) avoidance in male Sprague-Dawley rats. The three benzodiazepines increased shuttlebox avoidance acquisition, and their effects were prevented (antagonized) by flumazenil (10 mg/kg). The present results indicate that central benzodiazepine (BZ) receptors are involved in the anxiolytic effects of diazepam and triazolobenzodiazepines on the early acquisition of two-way active avoidance. © 1993 Academic Press.

Original language	English
Pages (from-to)	53-58
Journal	Pharmacological Research
Volume	28
Issue number	1
DOIs	https://doi.org/10.1006/phrs.1993.1109
Publication status	Published - 1 Jan 1993

Keywords

Adinazolam
Alprazolam
Anxiety
Diazepam
Flumazenil
Rats
Two-way active avoidance acquisition

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10.1006/phrs.1993.1109

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@article{20f853f8c1294879813dbe5da382211d,

title = "Flumazenil prevents the anxiolytic effects of diazepam, alprazolam and adinazolam on the early acquisition of two-way active avoidance",

abstract = "The effects of diazepam (DZ, 4 mg/kg), alprazolam (ALP, 1.25 mg/kg) and adinazolam (ADIN, 6 mg/kg), as well as their interaction with the benzodiazepine receptor antagonist flumazenil (Ro15-1788), were studied on the early acquisition of two-way active (shuttlebox) avoidance in male Sprague-Dawley rats. The three benzodiazepines increased shuttlebox avoidance acquisition, and their effects were prevented (antagonized) by flumazenil (10 mg/kg). The present results indicate that central benzodiazepine (BZ) receptors are involved in the anxiolytic effects of diazepam and triazolobenzodiazepines on the early acquisition of two-way active avoidance. {\textcopyright} 1993 Academic Press.",

keywords = "Adinazolam, Alprazolam, Anxiety, Diazepam, Flumazenil, Rats, Two-way active avoidance acquisition",

author = "Escorihuela, {R. M.} and A. Fern{\'a}ndez-Teruel and A. Zapata and N{\"u}{\~n}ez, {J. F.} and A. Tobe{\'n}a",

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T1 - Flumazenil prevents the anxiolytic effects of diazepam, alprazolam and adinazolam on the early acquisition of two-way active avoidance

AU - Escorihuela, R. M.

AU - Fernández-Teruel, A.

AU - Zapata, A.

AU - Nüñez, J. F.

AU - Tobeńa, A.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The effects of diazepam (DZ, 4 mg/kg), alprazolam (ALP, 1.25 mg/kg) and adinazolam (ADIN, 6 mg/kg), as well as their interaction with the benzodiazepine receptor antagonist flumazenil (Ro15-1788), were studied on the early acquisition of two-way active (shuttlebox) avoidance in male Sprague-Dawley rats. The three benzodiazepines increased shuttlebox avoidance acquisition, and their effects were prevented (antagonized) by flumazenil (10 mg/kg). The present results indicate that central benzodiazepine (BZ) receptors are involved in the anxiolytic effects of diazepam and triazolobenzodiazepines on the early acquisition of two-way active avoidance. © 1993 Academic Press.

AB - The effects of diazepam (DZ, 4 mg/kg), alprazolam (ALP, 1.25 mg/kg) and adinazolam (ADIN, 6 mg/kg), as well as their interaction with the benzodiazepine receptor antagonist flumazenil (Ro15-1788), were studied on the early acquisition of two-way active (shuttlebox) avoidance in male Sprague-Dawley rats. The three benzodiazepines increased shuttlebox avoidance acquisition, and their effects were prevented (antagonized) by flumazenil (10 mg/kg). The present results indicate that central benzodiazepine (BZ) receptors are involved in the anxiolytic effects of diazepam and triazolobenzodiazepines on the early acquisition of two-way active avoidance. © 1993 Academic Press.

KW - Adinazolam

KW - Alprazolam

KW - Anxiety

KW - Diazepam

KW - Flumazenil

KW - Rats

KW - Two-way active avoidance acquisition

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DO - 10.1006/phrs.1993.1109

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JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

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ER -