Abstract
The effects of diazepam (DZ, 4 mg/kg), alprazolam (ALP, 1.25 mg/kg) and adinazolam (ADIN, 6 mg/kg), as well as their interaction with the benzodiazepine receptor antagonist flumazenil (Ro15-1788), were studied on the early acquisition of two-way active (shuttlebox) avoidance in male Sprague-Dawley rats. The three benzodiazepines increased shuttlebox avoidance acquisition, and their effects were prevented (antagonized) by flumazenil (10 mg/kg). The present results indicate that central benzodiazepine (BZ) receptors are involved in the anxiolytic effects of diazepam and triazolobenzodiazepines on the early acquisition of two-way active avoidance. © 1993 Academic Press.
Original language | English |
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Pages (from-to) | 53-58 |
Journal | Pharmacological Research |
Volume | 28 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 1993 |
Keywords
- Adinazolam
- Alprazolam
- Anxiety
- Diazepam
- Flumazenil
- Rats
- Two-way active avoidance acquisition