Flumazenil prevents the anxiolytic effects of diazepam, alprazolam and adinazolam on the early acquisition of two-way active avoidance

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Abstract

The effects of diazepam (DZ, 4 mg/kg), alprazolam (ALP, 1.25 mg/kg) and adinazolam (ADIN, 6 mg/kg), as well as their interaction with the benzodiazepine receptor antagonist flumazenil (Ro15-1788), were studied on the early acquisition of two-way active (shuttlebox) avoidance in male Sprague-Dawley rats. The three benzodiazepines increased shuttlebox avoidance acquisition, and their effects were prevented (antagonized) by flumazenil (10 mg/kg). The present results indicate that central benzodiazepine (BZ) receptors are involved in the anxiolytic effects of diazepam and triazolobenzodiazepines on the early acquisition of two-way active avoidance. © 1993 Academic Press.
Original languageEnglish
Pages (from-to)53-58
JournalPharmacological Research
Volume28
Issue number1
DOIs
Publication statusPublished - 1 Jan 1993

Keywords

  • Adinazolam
  • Alprazolam
  • Anxiety
  • Diazepam
  • Flumazenil
  • Rats
  • Two-way active avoidance acquisition

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