Flow Injection Amperometric Determination of Pharmaceuticals

F. González, P. Tarin, Santiago Maspoch Andres, Marcel Blanco Romia

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13 Citations (Scopus)

Abstract

A new method is proposed for the flow injection determination of nicardipine and OPAP, [N‐(2‐oxo‐1‐pyrrolidinyl)‐acetyl]‐N′‐(3‐phenylprop‐2‐en‐2‐yl)piperazine, with amperometric detection at a fixed potential by oxidation on a glassy carbon electrode. The influence of the injected volume, flow rate, pH and electrolyte composition on the sensitivity is studied. In the proposed method, the effect of the analyte adsorption on the electrode surface is overcome. The response is linear over the range 0.3–50 mg/L for OPAP and 0.2–16 mg/L for nicardipine, their respective detection limits being 0.1 and 0.05 mg/L. Copyright © 1988 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Original languageEnglish
Pages (from-to)725-728
JournalArchiv der Pharmazie
Volume321
Issue number10
DOIs
Publication statusPublished - 1 Jan 1988

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