Flash tooth whitening: A friendly formulation based on a nanoencapsulated reductant

Clara Babot-Marquillas, María Jesús Sánchez-Martín*, Jorge Rodríguez-Martínez, Joan Estelrich, Maria Antonia Busquets, Manuel Valiente

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Tooth whitening materials have not undergone relevant advances in the last years. Current materials base their action on the oxidant activity of peroxides, which present the disadvantage of requiring long application times, along with unpleasant side effects of dental hypersensitivity (e.g. sharp pain). In this work, a novel tooth whitening formulation based on the encapsulation of a reducing agent (sodium metabisulfite) in liposomes is developed. An experimental design was applied to optimize the formulation in terms of whitening action and safety, using bovine teeth as in vitro model. Results were obtained by colorimetry, profilometry and nanoindentation techniques. The comparison with standard whitening treatments showed a similar whitening action of the optimized formulation but in remarkable shorter application times. Moreover, teeth roughness values obtained with the presented formulation conformed with ISO 28399. As mechanism of action, results obtained from fluorescent confocal microscopy showed the liposomal formulation to form a layer surrounding the enamel surface, enhancing the treatment efficacy in terms of diffusion of the protected reductant towards the enamel. The better efficiency of this formulation encourages its use as an alternative to current oxidative treatments.

Original languageEnglish
Article number111241
JournalColloids and Surfaces B: Biointerfaces
Publication statusPublished - Nov 2020


  • DPPC liposomes
  • Nanoencapsulation
  • Reducing agent
  • Sodium metabisulfite
  • Tooth whitening


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