Fit-for-purpose radio receptor assay for the determination of growth hormone secretagogues in urine

P. Ferro, R. Gutiérrez-Gallego, J. Bosch, M. Farré, J. Segura

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

© 2015 Society for Laboratory Automation and Screening. The everlasting pharmacological development is continuously producing new substances with potential doping abuse. Among these, secretagogues are very prone to misuse by athletes for their properties to release growth hormone (GH) and some limitations in the actual analytical methods to detect them. In this paper, an in-depth study on the key variables of the radio receptor method previously developed by our group is performed and a fit-for-purpose protocol is established. Thus, this sensitive and robust screening method is proposed as an intelligent and preventive antidoping method to detect new growth hormone secretagogues (GHSs) in exceptional suspicious urine samples obtained from athletes and will support the current detection methods based on liquid chromatography-mass spectrometry (LC-MS).
Original languageEnglish
Pages (from-to)1268-1276
JournalJournal of Biomolecular Screening
Volume20
Issue number10
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • doping abuse
  • doping substances
  • GHS-R1a receptor
  • growth hormone secretagogues
  • radio receptor assay

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