First experimental determination of two-bond 13C isotopic effects on 1H NMR chemical shifts

Juan Félix Espinosa, Teodor Parella

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    3 Citations (Scopus)


    For the first time, a simple NMR methodology is proposed for the accurate determination of the effect of the substitution of 12C by 13C on the chemical shifts of protons separated by two-bonds in small molecules in their natural abundance. © 2008 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)2562-2565
    JournalTetrahedron Letters
    Issue number16
    Publication statusPublished - 14 Apr 2008


    • 1D-TOCSY
    • 13 C isotopic effect
    • 13 C-satellites
    • 1 H chemical shift


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