First enantioselective synthesis of (-)-(Z)-2,3-methano-L-glutamic acid

José M. Jiménez, Rosa M. Ortuño

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27 Citations (Scopus)


(-)-(Z)-2,3-Methano-L-glutamic acid, a potential mGluR agonist, has been synthesized for the first time in 40% overall yield from a homochiral amino pentenoate as an easily available precursor. A conveniently protected (-)-(Z)-cyclo-aspartic acid derivative was the key intermediate, homologation of the carboxylic acid having been accomplished via the Arndt-Eistert procedure. Copyright (C) Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)3203-3208
JournalTetrahedron Asymmetry
Issue number11
Publication statusPublished - 8 Nov 1996


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