Abstract
(-)-(Z)-2,3-Methano-L-glutamic acid, a potential mGluR agonist, has been synthesized for the first time in 40% overall yield from a homochiral amino pentenoate as an easily available precursor. A conveniently protected (-)-(Z)-cyclo-aspartic acid derivative was the key intermediate, homologation of the carboxylic acid having been accomplished via the Arndt-Eistert procedure. Copyright (C) Elsevier Science Ltd.
Original language | English |
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Pages (from-to) | 3203-3208 |
Journal | Tetrahedron Asymmetry |
Volume | 7 |
Issue number | 11 |
DOIs | |
Publication status | Published - 8 Nov 1996 |