First detection of plasmid-encoded bla<inf>OXY</inf> β-Lactamase

J. J. González-López; A. Coelho; M. N. Larrosa; S. Lavilla; R. Bartolomé; G. Prats

doi:10.1128/AAC.01473-08

First detection of plasmid-encoded bla<inf>OXY</inf> β-Lactamase

J. J. González-López, A. Coelho, M. N. Larrosa, S. Lavilla, R. Bartolomé, G. Prats

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Three Klebsiella oxytoca isolates and one Klebsiella pneumoniae isolate from three children admitted to the Hematology Unit of Hospital Vall d'Hebron (Barcelona, Spain) exhibited a susceptibility pattern suggesting OXY β-lactamase hyperproduction. All the isolates contained a 95-kb plasmid that harbored blaOXY-1, which was transferred by electrotransformation but could not be self-transferred by conjugation. A qnrS1 gene was also harbored in the blaOXY-1-carrying plasmid. This is the first report of a plasmid-encoded OXY β-lactamase. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	3143-3146
Journal	Antimicrobial Agents and Chemotherapy
Volume	53
Issue number	7
DOIs	https://doi.org/10.1128/AAC.01473-08
Publication status	Published - 1 Jul 2009

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title = "First detection of plasmid-encoded blaOXY β-Lactamase",

abstract = "Three Klebsiella oxytoca isolates and one Klebsiella pneumoniae isolate from three children admitted to the Hematology Unit of Hospital Vall d'Hebron (Barcelona, Spain) exhibited a susceptibility pattern suggesting OXY β-lactamase hyperproduction. All the isolates contained a 95-kb plasmid that harbored blaOXY-1, which was transferred by electrotransformation but could not be self-transferred by conjugation. A qnrS1 gene was also harbored in the blaOXY-1-carrying plasmid. This is the first report of a plasmid-encoded OXY β-lactamase. Copyright {\textcopyright} 2009, American Society for Microbiology. All Rights Reserved.",

author = "Gonz{\'a}lez-L{\'o}pez, {J. J.} and A. Coelho and Larrosa, {M. N.} and S. Lavilla and R. Bartolom{\'e} and G. Prats",

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AU - González-López, J. J.

AU - Coelho, A.

AU - Larrosa, M. N.

AU - Lavilla, S.

AU - Bartolomé, R.

AU - Prats, G.

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AB - Three Klebsiella oxytoca isolates and one Klebsiella pneumoniae isolate from three children admitted to the Hematology Unit of Hospital Vall d'Hebron (Barcelona, Spain) exhibited a susceptibility pattern suggesting OXY β-lactamase hyperproduction. All the isolates contained a 95-kb plasmid that harbored blaOXY-1, which was transferred by electrotransformation but could not be self-transferred by conjugation. A qnrS1 gene was also harbored in the blaOXY-1-carrying plasmid. This is the first report of a plasmid-encoded OXY β-lactamase. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

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DO - 10.1128/AAC.01473-08

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